1kbo: Difference between revisions

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-[[Image:1kbo.png|left|200px]]
-{{STRUCTURE_1kbo|  PDB=1kbo  |  SCENE=  }}
+==Complex of Human recombinant NAD(P)H:Quinone Oxide reductase type 1 with 5-methoxy-1,2-dimethyl-3-(phenoxymethyl)indole-4,7-dione (ES1340)==
+<StructureSection load='1kbo' size='340' side='right'caption='[[1kbo]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-===Complex of Human recombinant NAD(P)H:Quinone Oxide reductase type 1 with 5-methoxy-1,2-dimethyl-3-(phenoxymethyl)indole-4,7-dione (ES1340)===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1kbo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KBO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KBO FirstGlance]. <br>
-{{ABSTRACT_PUBMED_11735396}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=340:5-METHOXY-1,2-DIMETHYL-3-(PHENOXYMETHYL)INDOLE-4,7-DIONE'>340</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kbo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kbo OCA], [https://pdbe.org/1kbo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kbo RCSB], [https://www.ebi.ac.uk/pdbsum/1kbo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kbo ProSAT]</span></td></tr>
-[[1kbo]] is a 4 chain structure of [[Quinone reductase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KBO OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NQO1_HUMAN NQO1_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kb/1kbo_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kbo ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Quinone reductase|Quinone reductase]]
+*[[Quinone reductase 3D structures|Quinone reductase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:011735396</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Amzel, L M.]]
+[[Category: Large Structures]]
-[[Category: Bianchet, M A.]]
+[[Category: Amzel LM]]
-[[Category: Faig, M.]]
+[[Category: Bianchet MA]]
-[[Category: Flavoenzyme]]
+[[Category: Faig M]]
-[[Category: Oxidoreductase]]
-[[Category: Prodrug-enzyme complex]]