1qbg: Difference between revisions

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-[[Image:1qbg.png|left|200px]]
-{{STRUCTURE_1qbg|  PDB=1qbg  |  SCENE=  }}
+==CRYSTAL STRUCTURE OF HUMAN DT-DIAPHORASE (NAD(P)H OXIDOREDUCTASE)==
+<StructureSection load='1qbg' size='340' side='right'caption='[[1qbg]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-===CRYSTAL STRUCTURE OF HUMAN DT-DIAPHORASE (NAD(P)H OXIDOREDUCTASE)===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1qbg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QBG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QBG FirstGlance]. <br>
-{{ABSTRACT_PUBMED_10543876}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qbg OCA], [https://pdbe.org/1qbg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qbg RCSB], [https://www.ebi.ac.uk/pdbsum/1qbg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qbg ProSAT]</span></td></tr>
-[[1qbg]] is a 4 chain structure of [[Quinone reductase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QBG OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NQO1_HUMAN NQO1_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qb/1qbg_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qbg ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Quinone reductase|Quinone reductase]]
+*[[Quinone reductase 3D structures|Quinone reductase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:010543876</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Baumann, U.]]
+[[Category: Large Structures]]
-[[Category: Bennett, M.]]
+[[Category: Baumann U]]
-[[Category: Gregory, D S.]]
+[[Category: Bennett M]]
-[[Category: Hobbs, S M.]]
+[[Category: Gregory DS]]
-[[Category: Neidle, S.]]
+[[Category: Hobbs SM]]
-[[Category: Sanderson, M R.]]
+[[Category: Neidle S]]
-[[Category: Skelly, J V.]]
+[[Category: Sanderson MR]]
-[[Category: Suter, D A.]]
+[[Category: Skelly JV]]
-[[Category: Dt-diaphorase]]
+[[Category: Suter DA]]
-[[Category: Fad]]
-[[Category: Oxidoreductase]]
-[[Category: Quinone]]