3k23: Difference between revisions

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-[[Image:3k23.png|left|200px]]
-{{STRUCTURE_3k23|  PDB=3k23  |  SCENE=  }}
+==Glucocorticoid Receptor with Bound D-prolinamide 11==
+<StructureSection load='3k23' size='340' side='right'caption='[[3k23]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-===Glucocorticoid Receptor with Bound D-prolinamide 11===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3k23]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K23 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_19822747}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JZN:1-{[3-(4-{[(2R)-4-(5-FLUORO-2-METHOXYPHENYL)-2-HYDROXY-4-METHYL-2-(TRIFLUOROMETHYL)PENTYL]AMINO}-6-METHYL-1H-INDAZOL-1-YL)PHENYL]CARBONYL}-D-PROLINAMIDE'>JZN</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k23 OCA], [https://pdbe.org/3k23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k23 RCSB], [https://www.ebi.ac.uk/pdbsum/3k23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k23 ProSAT]</span></td></tr>
-[[3k23]] is a 6 chain structure of [[Glucocorticoid receptor]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K23 OCA].
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[https://omim.org/entry/138040 138040]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.<ref>PMID:21664385</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k2/3k23_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k23 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Glucocorticoid receptor|Glucocorticoid receptor]]
+*[[Glucocorticoid receptor 3D structures|Glucocorticoid receptor 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:019822747</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Biggadike, K B.]]
+[[Category: Large Structures]]
-[[Category: Bledsoe, R K.]]
+[[Category: Biggadike KB]]
-[[Category: Madauss, K P.]]
+[[Category: Bledsoe RK]]
-[[Category: McLay, I M.]]
+[[Category: Madauss KP]]
-[[Category: Williams, S P.]]
+[[Category: McLay IM]]
-[[Category: Activator]]
+[[Category: Williams SP]]
-[[Category: Alpha helical sandwich]]
-[[Category: Alternative initiation]]
-[[Category: Chromatin regulator]]
-[[Category: Disease mutation]]
-[[Category: Dna-binding]]
-[[Category: Glucocorticoid receptor]]
-[[Category: Glucocorticoid]]
-[[Category: Gr]]
-[[Category: Meta-channel]]
-[[Category: Metal-binding]]
-[[Category: Nuclear receptor]]
-[[Category: Nucleus]]
-[[Category: Pseudohermaphroditism]]
-[[Category: Receptor]]
-[[Category: Steroid hormone receptor]]
-[[Category: Steroid-binding]]
-[[Category: Transcription]]
-[[Category: Transcription regulation]]
-[[Category: Zinc-finger]]