3lnx: Difference between revisions

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-[[Image:3lnx.png|left|200px]]
-{{STRUCTURE_3lnx|  PDB=3lnx  |  SCENE=  }}
+==Second PDZ domain from human PTP1E==
+<StructureSection load='3lnx' size='340' side='right'caption='[[3lnx]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
-===Second PDZ domain from human PTP1E===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3lnx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LNX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LNX FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.642&#8491;</td></tr>
-==About this Structure==
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
-[[3lnx]] is a 6 chain structure of [[Proten tyrosine phosphatase]] and [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LNX OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lnx OCA], [https://pdbe.org/3lnx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lnx RCSB], [https://www.ebi.ac.uk/pdbsum/3lnx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lnx ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PTN13_HUMAN PTN13_HUMAN] Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.<ref>PMID:15611135</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ln/3lnx_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lnx ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Proten tyrosine phosphatase|Proten tyrosine phosphatase]]
+*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
-*[[Tyrosine phosphatase|Tyrosine phosphatase]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
+[[Category: Large Structures]]
-[[Category: Chang, A.]]
+[[Category: Chang A]]
-[[Category: Ke, H.]]
+[[Category: Ke H]]
-[[Category: Lee, A L.]]
+[[Category: Lee AL]]
-[[Category: Phillips, G N.]]
+[[Category: Phillips Jr GN]]
-[[Category: Zhang, J.]]
+[[Category: Zhang J]]
-[[Category: Center for eukaryotic structural genomic]]
-[[Category: Cesg]]
-[[Category: Cytoskeleton]]
-[[Category: Pdz2]]
-[[Category: Protein structure initiative]]
-[[Category: Psi-2]]
-[[Category: Signaling protein]]
-[[Category: Structural genomic]]