1rsd: Difference between revisions

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[[Image:1rsd.png|left|200px]]


{{STRUCTURE_1rsd|  PDB=1rsd  |  SCENE=  }}
==DHNA complex with 3-(5-Amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-[2-(2-hydroxymethyl-phenylsulfanyl)-benzyl]-benzamide==
 
<StructureSection load='1rsd' size='340' side='right'caption='[[1rsd]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
===DHNA complex with 3-(5-Amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-[2-(2-hydroxymethyl-phenylsulfanyl)-benzyl]-benzamide===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1rsd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RSD FirstGlance]. <br>
{{ABSTRACT_PUBMED_15027862}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PSB:3-(5-AMINO-7-HYDROXY-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-2-YL)-N-[2-(2-(HYDROXYMETHYL-PHENYLSULFANYL)-BENZYL]-BENZAMIDE'>PSB</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rsd OCA], [https://pdbe.org/1rsd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rsd RCSB], [https://www.ebi.ac.uk/pdbsum/1rsd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rsd ProSAT]</span></td></tr>
[[1rsd]] is a 1 chain structure of [[Aldolase]] with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RSD OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/FOLB_STAAU FOLB_STAAU] Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rs/1rsd_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rsd ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Aldolase|Aldolase]]
*[[Aldolase 3D structures|Aldolase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:015027862</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Dihydroneopterin aldolase]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
[[Category: Betz, S F.]]
[[Category: Betz SF]]
[[Category: Beutel, B A.]]
[[Category: Beutel BA]]
[[Category: Condroski, K R.]]
[[Category: Condroski KR]]
[[Category: Harlan, J E.]]
[[Category: Harlan JE]]
[[Category: Jakob, C G.]]
[[Category: Jakob CG]]
[[Category: Lerner, C G.]]
[[Category: Lerner CG]]
[[Category: Magdalinos, P.]]
[[Category: Magdalinos P]]
[[Category: McCall, J O.]]
[[Category: McCall JO]]
[[Category: Meadows, R P.]]
[[Category: Meadows RP]]
[[Category: Merrick, S M.]]
[[Category: Merrick SM]]
[[Category: Nienaber, V L.]]
[[Category: Nienaber VL]]
[[Category: Sanders, W J.]]
[[Category: Sanders WJ]]
[[Category: Severin, J M.]]
[[Category: Severin JM]]
[[Category: Stamper, G F.]]
[[Category: Stamper GF]]
[[Category: Stoll, V S.]]
[[Category: Stoll VS]]
[[Category: Swanson, S J.]]
[[Category: Swanson SJ]]
[[Category: Wagner, R.]]
[[Category: Wagner R]]
[[Category: Walter, K A.]]
[[Category: Walter KA]]
[[Category: 8-dihydroneopterin aldolase]]
[[Category: Dhna]]
[[Category: Lyase]]

Latest revision as of 11:25, 14 February 2024

DHNA complex with 3-(5-Amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-[2-(2-hydroxymethyl-phenylsulfanyl)-benzyl]-benzamideDHNA complex with 3-(5-Amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-[2-(2-hydroxymethyl-phenylsulfanyl)-benzyl]-benzamide

Structural highlights

1rsd is a 1 chain structure with sequence from Staphylococcus aureus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FOLB_STAAU Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1rsd, resolution 2.50Å

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