3lxg: Difference between revisions

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[[Image:3lxg.png|left|200px]]


{{STRUCTURE_3lxg|  PDB=3lxg  |  SCENE=  }}
==Crystal structure of rat phosphodiesterase 10A in complex with ligand WEB-3==
 
<StructureSection load='3lxg' size='340' side='right'caption='[[3lxg]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
===Crystal structure of rat phosphodiesterase 10A in complex with ligand WEB-3===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3lxg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LXG FirstGlance]. <br>
{{ABSTRACT_PUBMED_20450197}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=Z73:2-METHOXY-6,7-DIMETHYL-9-PROPYLIMIDAZO[1,5-A]PYRIDO[3,2-E]PYRAZINE'>Z73</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lxg OCA], [https://pdbe.org/3lxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lxg RCSB], [https://www.ebi.ac.uk/pdbsum/3lxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lxg ProSAT]</span></td></tr>
[[3lxg]] is a 1 chain structure of [[Phosphodiesterase]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LXG OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDE10_RAT PDE10_RAT] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:10583409</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lx/3lxg_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lxg ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Phosphodiesterase|Phosphodiesterase]]
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:020450197</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Jestel, A.]]
[[Category: Jestel A]]
[[Category: Mosbacher, T.]]
[[Category: Mosbacher T]]
[[Category: Steinbacher, S.]]
[[Category: Steinbacher S]]
[[Category: Allosteric enzyme]]
[[Category: Camp]]
[[Category: Camp-binding]]
[[Category: Catalytic domain]]
[[Category: Cgmp]]
[[Category: Cgmp-binding]]
[[Category: Hydrolase]]
[[Category: Metal-binding]]
[[Category: Nucleotide-binding]]
[[Category: Phosphodiesterase 10a]]

Latest revision as of 13:22, 21 February 2024

Crystal structure of rat phosphodiesterase 10A in complex with ligand WEB-3Crystal structure of rat phosphodiesterase 10A in complex with ligand WEB-3

Structural highlights

3lxg is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PDE10_RAT Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Fujishige K, Kotera J, Omori K. Striatum- and testis-specific phosphodiesterase PDE10A isolation and characterization of a rat PDE10A. Eur J Biochem. 1999 Dec;266(3):1118-27. PMID:10583409

3lxg, resolution 2.30Å

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