2hc0: Difference between revisions

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-[[Image:2hc0.png|left|200px]]
-{{STRUCTURE_2hc0|  PDB=2hc0  |  SCENE=  }}
+==Structure of HIV protease 6X mutant in complex with AB-2.==
+<StructureSection load='2hc0' size='340' side='right'caption='[[2hc0]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
-===Structure of HIV protease 6X mutant in complex with AB-2.===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2hc0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HC0 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
-==About this Structure==
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AB2:[1-((1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL)-1H-1,2,3-TRIAZOL-4-YL]METHYL+(1R,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YLCARBAMATE'>AB2</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
-[[2hc0]] is a 2 chain structure of [[Virus protease]] with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HC0 OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hc0 OCA], [https://pdbe.org/2hc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hc0 RCSB], [https://www.ebi.ac.uk/pdbsum/2hc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hc0 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q9E3M8_HV1 Q9E3M8_HV1]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hc/2hc0_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hc0 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Virus protease|Virus protease]]
+*[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]]
-[[Category: HIV-1 retropepsin]]
+__TOC__
+</StructureSection>
 [[Category: Human immunodeficiency virus 1]]
-[[Category: Brik, A.]]
+[[Category: Large Structures]]
-[[Category: Elder, J H.]]
+[[Category: Brik A]]
-[[Category: Heaslet, H.]]
+[[Category: Elder JH]]
-[[Category: Lin, Y C.]]
+[[Category: Heaslet H]]
-[[Category: Stout, C D.]]
+[[Category: Lin Y-C]]
-[[Category: Aspartyl]]
+[[Category: Stout CD]]
-[[Category: Hiv]]
-[[Category: Hydrolase]]
-[[Category: Mutant]]
-[[Category: Protease]]