1i0e: Difference between revisions

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-[[Image:1i0e.png|left|200px]]
-{{STRUCTURE_1i0e|  PDB=1i0e  |  SCENE=  }}
+==CRYSTAL STRUCTURE OF CREATINE KINASE FROM HUMAN MUSCLE==
+<StructureSection load='1i0e' size='340' side='right'caption='[[1i0e]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
-===CRYSTAL STRUCTURE OF CREATINE KINASE FROM HUMAN MUSCLE===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1i0e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I0E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I0E FirstGlance]. <br>
-{{ABSTRACT_PUBMED_11517911}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i0e OCA], [https://pdbe.org/1i0e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i0e RCSB], [https://www.ebi.ac.uk/pdbsum/1i0e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i0e ProSAT]</span></td></tr>
-==About this Structure==
+</table>
-[[1i0e]] is a 4 chain structure of [[Creatine Kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I0E OCA].
+== Function ==
+[https://www.uniprot.org/uniprot/KCRM_HUMAN KCRM_HUMAN] Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i0/1i0e_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i0e ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Creatine Kinase|Creatine Kinase]]
+*[[Creatine kinase 3D structures|Creatine kinase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:011517911</ref><references group="xtra"/>
-[[Category: Creatine kinase]]
 [[Category: Homo sapiens]]
-[[Category: Lin, Z J.]]
+[[Category: Large Structures]]
-[[Category: Shen, Y Q.]]
+[[Category: Lin Z-J]]
-[[Category: Tang, L.]]
+[[Category: Shen Y-Q]]
-[[Category: Zhou, H M.]]
+[[Category: Tang L]]
-[[Category: Dimer]]
+[[Category: Zhou H-M]]
-[[Category: Double helix]]
-[[Category: Transferase]]