3b8d: Difference between revisions

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[[Image:3b8d.png|left|200px]]


{{STRUCTURE_3b8d|  PDB=3b8d  |  SCENE=  }}
==Fructose 1,6-bisphosphate aldolase from rabbit muscle==
 
<StructureSection load='3b8d' size='340' side='right'caption='[[3b8d]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
===Fructose 1,6-bisphosphate aldolase from rabbit muscle===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3b8d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ewg 1ewg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B8D FirstGlance]. <br>
{{ABSTRACT_PUBMED_11779856}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b8d OCA], [https://pdbe.org/3b8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b8d RCSB], [https://www.ebi.ac.uk/pdbsum/3b8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b8d ProSAT]</span></td></tr>
[[3b8d]] is a 4 chain structure of [[Aldolase]] with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ewg 1ewg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B8D OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/ALDOA_RABIT ALDOA_RABIT] Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein.<ref>PMID:17329259</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/3b8d_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b8d ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Aldolase|Aldolase]]
*[[Aldolase 3D structures|Aldolase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:011779856</ref><references group="xtra"/>
__TOC__
[[Category: Fructose-bisphosphate aldolase]]
</StructureSection>
[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
[[Category: Maurady, A.]]
[[Category: Maurady A]]
[[Category: Sygusch, J.]]
[[Category: Sygusch J]]
[[Category: Aldolase]]
[[Category: Glycolysis]]
[[Category: Lyase]]
[[Category: Phosphorylation]]
[[Category: Schiff base]]

Latest revision as of 12:27, 21 February 2024

Fructose 1,6-bisphosphate aldolase from rabbit muscleFructose 1,6-bisphosphate aldolase from rabbit muscle

Structural highlights

3b8d is a 4 chain structure with sequence from Oryctolagus cuniculus. This structure supersedes the now removed PDB entry 1ewg. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ALDOA_RABIT Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ St-Jean M, Izard T, Sygusch J. A hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with Wiskott-Aldrich syndrome protein. J Biol Chem. 2007 May 11;282(19):14309-15. Epub 2007 Feb 27. PMID:17329259 doi:10.1074/jbc.M611505200

3b8d, resolution 2.00Å

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