1tf9: Difference between revisions

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[[Image:1tf9.png|left|200px]]


{{STRUCTURE_1tf9|  PDB=1tf9  |  SCENE=  }}
==Streptomyces griseus aminopeptidase complexed with P-Iodo-L-Phenylalanine==
 
<StructureSection load='1tf9' size='340' side='right'caption='[[1tf9]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
===Streptomyces griseus aminopeptidase complexed with P-Iodo-L-Phenylalanine===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1tf9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_griseus Streptomyces griseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TF9 FirstGlance]. <br>
{{ABSTRACT_PUBMED_15388919}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PHI:IODO-PHENYLALANINE'>PHI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tf9 OCA], [https://pdbe.org/1tf9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tf9 RCSB], [https://www.ebi.ac.uk/pdbsum/1tf9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tf9 ProSAT]</span></td></tr>
[[1tf9]] is a 1 chain structure of [[Aminopeptidase]] and [[Streptomyces griseus Aminopeptidase (SGAP)]] with sequence from [http://en.wikipedia.org/wiki/Streptomyces_griseus Streptomyces griseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF9 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/APX_STRGG APX_STRGG] An exopeptidase specific for larger hydrophobic amino acids (especially leucine), no cleavage occurs if the next residue is proline (PubMed:8444149).<ref>PMID:2503378</ref> <ref>PMID:8444149</ref> <ref>PMID:8665903</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tf/1tf9_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tf9 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Aminopeptidase|Aminopeptidase]]
*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
*[[Streptomyces griseus Aminopeptidase (SGAP)|Streptomyces griseus Aminopeptidase (SGAP)]]
*[[Streptomyces griseus Aminopeptidase (SGAP)|Streptomyces griseus Aminopeptidase (SGAP)]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:015388919</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptomyces griseus]]
[[Category: Streptomyces griseus]]
[[Category: Blumberg, S.]]
[[Category: Blumberg S]]
[[Category: Gilboa, R.]]
[[Category: Gilboa R]]
[[Category: Reiland, V.]]
[[Category: Reiland V]]
[[Category: Schomburg, D.]]
[[Category: Schomburg D]]
[[Category: Shoham, G.]]
[[Category: Shoham G]]
[[Category: Shoham, Y.]]
[[Category: Shoham Y]]
[[Category: Spungin-Bialik, A.]]
[[Category: Spungin-Bialik A]]
[[Category: Calcium activation]]
[[Category: Double-zinc metalloproteinase]]
[[Category: Hydrolase]]
[[Category: Protein-inhibitor complex]]

Latest revision as of 11:40, 1 May 2024

Streptomyces griseus aminopeptidase complexed with P-Iodo-L-PhenylalanineStreptomyces griseus aminopeptidase complexed with P-Iodo-L-Phenylalanine

Structural highlights

1tf9 is a 1 chain structure with sequence from Streptomyces griseus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.3Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

APX_STRGG An exopeptidase specific for larger hydrophobic amino acids (especially leucine), no cleavage occurs if the next residue is proline (PubMed:8444149).[1] [2] [3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Spungin A, Blumberg S. Streptomyces griseus aminopeptidase is a calcium-activated zinc metalloprotein. Purification and properties of the enzyme. Eur J Biochem. 1989 Aug 1;183(2):471-7. PMID:2503378 doi:10.1111/j.1432-1033.1989.tb14952.x
  2. ↑ Ben-Meir D, Spungin A, Ashkenazi R, Blumberg S. Specificity of Streptomyces griseus aminopeptidase and modulation of activity by divalent metal ion binding and substitution. Eur J Biochem. 1993 Feb 15;212(1):107-12. PMID:8444149 doi:10.1111/j.1432-1033.1993.tb17639.x
  3. ↑ Maras B, Greenblatt HM, Shoham G, Spungin-Bialik A, Blumberg S, Barra D. Aminopeptidase from Streptomyces griseus: primary structure and comparison with other zinc-containing aminopeptidases. Eur J Biochem. 1996 Mar 15;236(3):843-6. PMID:8665903 doi:10.1111/j.1432-1033.1996.00843.x

1tf9, resolution 1.30Å

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