3c66: Difference between revisions

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-[[Image:3c66.png|left|200px]]
-{{STRUCTURE_3c66|  PDB=3c66  |  SCENE=  }}
+==Yeast poly(A) polymerase in complex with Fip1 residues 80-105==
+<StructureSection load='3c66' size='340' side='right'caption='[[3c66]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-===Yeast poly(A) polymerase in complex with Fip1 residues 80-105===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3c66]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C66 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_18537269}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c66 OCA], [https://pdbe.org/3c66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c66 RCSB], [https://www.ebi.ac.uk/pdbsum/3c66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c66 ProSAT]</span></td></tr>
-[[3c66]] is a 4 chain structure of [[Poly(A) Polymerase]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C66 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PAP_YEAST PAP_YEAST] Polymerase component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB.<ref>PMID:17850751</ref> <ref>PMID:18537269</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c6/3c66_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c66 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Poly(A) Polymerase|Poly(A) Polymerase]]
+*[[Poly(A) polymerase 3D structures|Poly(A) polymerase 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:018537269</ref><references group="xtra"/>
+__TOC__
-[[Category: Polynucleotide adenylyltransferase]]
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Saccharomyces cerevisiae]]
-[[Category: Bohm, A.]]
+[[Category: Saccharomyces cerevisiae S288C]]
-[[Category: Meinke, G.]]
+[[Category: Bohm A]]
-[[Category: Mrna processing]]
+[[Category: Meinke G]]
-[[Category: Nucleus]]
-[[Category: Peptide-protein complex]]
-[[Category: Phosphoprotein]]
-[[Category: Rna-binding]]
-[[Category: Transferase]]