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==Eric Martz's Favorites== | ==Eric Martz's Favorites== | ||
Eric | *1995-1997: [[Recoverin, a calcium-activated myristoyl switch]]. Calcium induces this protein to undergo a huge conformational change, literally turning one domain inside out. The N-terminal myristic acid goes from being buried within the hydrophobic core of a protein domain to being exposed, facilitating the attachment of this enzyme to disc membranes in rod cells in the eye. [[Morphs]] of this transition are [[Recoverin, a calcium-activated myristoyl switch|shown]]. | ||
* 2004 - [[Lac repressor]] binding to DNA stabilizes a kink in the operator, due to sequence-specific [[hydrogen bonds|hydrogen bonding]] opening the minor groove of the DNA. The solution of non-specific binding in 2004 ([[1osl]]) made possible a [[Lac repressor|morph of the DNA bending during specific recognition by lac repressor]]. | |||
* 2004 - [[The Bacterial Flagellar Hook]], a molecular universal joint. | |||
* 2006 - '''Tamiflu bound to avian influenza neuraminidase N1''', [[2hu4]] has tamiflu bound, while [[2hty]] lacks this ligand. Tamiflu was designed for N2/N9, not N1. Its antiviral activity via N1 is fortunate but surprising. Comparison of these two structures shows that tamiflu pulls N1 loop 147-152 into close contact, a case of "induced fit". Another surprise was a cavity near tamiflu that could serve as a target for designing better anti-avian influenza drugs. | |||
** For the full story, please see [[Avian Influenza Neuraminidase, Tamiflu and Relenza]] which includes a morph of the induced fit, and visualization of the cavity.. | |||
** [http://www.umass.edu/molvis/martz/lectures/labmolgen/n1tami.htm Background] slides for a lecture. | |||
** [http://www.umass.edu/molvis/martz/lectures/labmolgen/index.htm Lesson plan on this topic]. | |||
To be added: MHC class I; domain-switched antibody. | |||
==See Also== | |||
* [http://atlas.molviz.org Atlas of Macromolecules] -- an arbitrary list of beautiful, amazing, interesting and high-impact structures gathered by [[User:Eric Martz]]. It includes ''Magnificant Molecular Machines'', ''Unusual Tertiary and Quaternary Structures'', and over a dozen other categories containing over 150 PDB entries. Each structure is liked for further exploration in Proteopedia, [[FirstGlance in Jmol]], and [[Protein Explorer]]. | |||
*[[Highest impact structures]] which includes ''Structures saving the most lives''. | |||