2lua: Difference between revisions

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'''Unreleased structure'''


The entry 2lua is ON HOLD  until Paper Publication
==Solution structure of CXC domain of MSL2==
 
<StructureSection load='2lua' size='340' side='right'caption='[[2lua]]' scene=''>
Authors: Feng, Y., Ye, K., Zheng, S., Wang, J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2lua]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LUA FirstGlance]. <br>
Description: Solution structure of CXC domain of MSL2
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lua OCA], [https://pdbe.org/2lua PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lua RCSB], [https://www.ebi.ac.uk/pdbsum/2lua PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lua ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MSL2_DROME MSL2_DROME] The Msl proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Msl-2 is required for translation and/or stability of msl-1 in males. In complex with msl-1, acts as an E3 ubiquitin ligase that promotes ubiquitination of histone H2B.<ref>PMID:21726816</ref> <ref>PMID:7588059</ref> <ref>PMID:7781064</ref> <ref>PMID:7796814</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Feng Y]]
[[Category: Wang J]]
[[Category: Ye K]]
[[Category: Zheng S]]

Latest revision as of 09:57, 1 May 2024

Solution structure of CXC domain of MSL2Solution structure of CXC domain of MSL2

Structural highlights

2lua is a 1 chain structure with sequence from Drosophila melanogaster. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MSL2_DROME The Msl proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Msl-2 is required for translation and/or stability of msl-1 in males. In complex with msl-1, acts as an E3 ubiquitin ligase that promotes ubiquitination of histone H2B.[1] [2] [3] [4]

References

  1. ↑ Wu L, Zee BM, Wang Y, Garcia BA, Dou Y. The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. Mol Cell. 2011 Jul 8;43(1):132-44. doi: 10.1016/j.molcel.2011.05.015. PMID:21726816 doi:http://dx.doi.org/10.1016/j.molcel.2011.05.015
  2. ↑ Bashaw GJ, Baker BS. The msl-2 dosage compensation gene of Drosophila encodes a putative DNA-binding protein whose expression is sex specifically regulated by Sex-lethal. Development. 1995 Oct;121(10):3245-58. PMID:7588059
  3. ↑ Kelley RL, Solovyeva I, Lyman LM, Richman R, Solovyev V, Kuroda MI. Expression of msl-2 causes assembly of dosage compensation regulators on the X chromosomes and female lethality in Drosophila. Cell. 1995 Jun 16;81(6):867-77. PMID:7781064
  4. ↑ Zhou S, Yang Y, Scott MJ, Pannuti A, Fehr KC, Eisen A, Koonin EV, Fouts DL, Wrightsman R, Manning JE, et al.. Male-specific lethal 2, a dosage compensation gene of Drosophila, undergoes sex-specific regulation and encodes a protein with a RING finger and a metallothionein-like cysteine cluster. EMBO J. 1995 Jun 15;14(12):2884-95. PMID:7796814
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