1wt3: Difference between revisions

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[[Image:1wt3.png|left|200px]]


{{STRUCTURE_1wt3|  PDB=1wt3  |  SCENE=  }}
==Mutant human ABO(H) blood group glycosyltransferase with bound UDP and acceptor==
 
<StructureSection load='1wt3' size='340' side='right'caption='[[1wt3]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
===Mutant human ABO(H) blood group glycosyltransferase with bound UDP and acceptor===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1wt3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WT3 FirstGlance]. <br>
{{ABSTRACT_PUBMED_15475562}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BHG:2-HEXYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL'>BHG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wt3 OCA], [https://pdbe.org/1wt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wt3 RCSB], [https://www.ebi.ac.uk/pdbsum/1wt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wt3 ProSAT]</span></td></tr>
[[1wt3]] is a 1 chain structure of [[Glycosyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WT3 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wt/1wt3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wt3 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Glycosyltransferase|Glycosyltransferase]]
*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:015475562</ref><references group="xtra"/>
[[Category: Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Barry, C H.]]
[[Category: Large Structures]]
[[Category: Blancher, A.]]
[[Category: Barry CH]]
[[Category: Borisova, S N.]]
[[Category: Blancher A]]
[[Category: Evans, S V.]]
[[Category: Borisova SN]]
[[Category: Lee, H J.]]
[[Category: Evans SV]]
[[Category: Palcic, M M.]]
[[Category: Lee HJ]]
[[Category: Seto, N O.L.]]
[[Category: Palcic MM]]
[[Category: Zheng, R B.]]
[[Category: Seto NOL]]
[[Category: Transferase]]
[[Category: Zheng RB]]

Latest revision as of 16:34, 13 March 2024

Mutant human ABO(H) blood group glycosyltransferase with bound UDP and acceptorMutant human ABO(H) blood group glycosyltransferase with bound UDP and acceptor

Structural highlights

1wt3 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BGAT_HUMAN This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1wt3, resolution 1.80Å

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