4eql: Difference between revisions

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-[[Image:4eql.jpg|left|200px]]
-{{STRUCTURE_4eql|  PDB=4eql  |  SCENE=  }}
+==Crystal Structure of GH3.12 in complex with AMP and salicylate==
+<StructureSection load='4eql' size='340' side='right'caption='[[4eql]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-===Crystal Structure of GH3.12 in complex with AMP and salicylate===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4eql]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EQL FirstGlance]. <br>
-{{ABSTRACT_PUBMED_22628555}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=SAL:2-HYDROXYBENZOIC+ACID'>SAL</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eql OCA], [https://pdbe.org/4eql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eql RCSB], [https://www.ebi.ac.uk/pdbsum/4eql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eql ProSAT]</span></td></tr>
-[[4eql]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EQL OCA].
+</table>
+== Function ==
-==Reference==
+[https://www.uniprot.org/uniprot/GH312_ARATH GH312_ARATH] Catalyzes the conjugation of specific amino acids (e.g. Glu and possibly His, Lys, and Met) to their preferred acyl substrates (e.g. 4-substituted benzoates), in a magnesium ion- and ATP-dependent manner. Can use 4-substituted benzoates such as 4-aminobenzoate (pABA), 4-fluorobenzoate and 4-hydroxybenzoate (4-HBA), and, to a lesser extent, benzoate, vanillate and trans-cinnamate, but not 2-substituted benzoates and salicylic acid (SA), as conjugating acyl substrates. Involved in both basal and induced resistance in a SA-dependent manner. Confers resistance to virulent and avirulent pathogens (at least bacteria and oomycetes), and promotes SA glucosides accumulation. Required for the establishment of hyper-sensitive response (HR) upon incompatible interaction and subsequent systemic acquired resistance (SAR).<ref>PMID:18266921</ref> <ref>PMID:10224270</ref> <ref>PMID:11846877</ref> <ref>PMID:16353557</ref> <ref>PMID:17918621</ref> <ref>PMID:17521413</ref> <ref>PMID:17468220</ref> <ref>PMID:19189963</ref>
-<ref group="xtra">PMID:022628555</ref><references group="xtra"/>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Arabidopsis thaliana]]
-[[Category: Herrmann, J.]]
+[[Category: Large Structures]]
-[[Category: Jez, J.]]
+[[Category: Herrmann J]]
-[[Category: Nanao, M.]]
+[[Category: Jez J]]
-[[Category: Westfall, C.]]
+[[Category: Nanao M]]
-[[Category: Zubieta, C.]]
+[[Category: Westfall C]]
-[[Category: Acyl adenylase]]
+[[Category: Zubieta C]]
-[[Category: Amino acid conjugation]]
-[[Category: Firefly luciferase family]]
-[[Category: Ligase]]