2kxq: Difference between revisions

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-[[Image:2kxq.png|left|200px]]
-<!--
+==Solution Structure of Smurf2 WW2 and WW3 bound to Smad7 PY motif containing peptide==
-The line below this paragraph, containing "STRUCTURE_2kxq", creates the "Structure Box" on the page.
+<StructureSection load='2kxq' size='340' side='right'caption='[[2kxq]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2kxq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KXQ FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kxq OCA], [https://pdbe.org/2kxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kxq RCSB], [https://www.ebi.ac.uk/pdbsum/2kxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kxq ProSAT]</span></td></tr>
-{{STRUCTURE_2kxq|  PDB=2kxq  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SMUF2_HUMAN SMUF2_HUMAN] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.<ref>PMID:11389444</ref> <ref>PMID:12717440</ref>
-===Solution Structure of Smurf2 WW2 and WW3 bound to Smad7 PY motif containing peptide===
+==See Also==
+*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_20937913}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 20937913 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_20937913}}
-==About this Structure==
-[[2kxq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXQ OCA].
-==Reference==
-<ref group="xtra">PMID:020937913</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Chong, A.]]
+[[Category: Large Structures]]
-[[Category: Forman-Kay, J D.]]
+[[Category: Chong A]]
-[[Category: Lin, H.]]
+[[Category: Forman-Kay JD]]
-[[Category: Wrana, J.]]
+[[Category: Lin H]]
-[[Category: Modular binding]]
+[[Category: Wrana J]]
-[[Category: Protein binding]]
-[[Category: Py motif]]
-[[Category: Smurf2]]
-[[Category: Tgf-beta]]
-[[Category: Ww]]