3rv8: Difference between revisions

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[[Image:3rv8.png|left|200px]]


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==Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Cyclopropyl R-Group==
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<StructureSection load='3rv8' size='340' side='right'caption='[[3rv8]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3rv8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RV8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RVC:3-{[(Z)-1-CARBOXY-2-CYCLOPROPYLETHENYL]OXY}-2-HYDROXYBENZOIC+ACID'>RVC</scene>, <scene name='pdbligand=VCE:3-{[(E)-1-CARBOXY-2-CYCLOPROPYLETHENYL]OXY}-2-HYDROXYBENZOIC+ACID'>VCE</scene></td></tr>
{{STRUCTURE_3rv8|  PDB=3rv8  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rv8 OCA], [https://pdbe.org/3rv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rv8 RCSB], [https://www.ebi.ac.uk/pdbsum/3rv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rv8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MBTI_MYCTU MBTI_MYCTU] Mediates the production of salicylate from chorismate via an isochorismate intermediate. Presents both isochorismate synthase and isochorismate-pyruvate lyase activities. Salycilate is the starter unit in the production of the virulence-conferring salicylate-based siderophore mycobactin.<ref>PMID:16923875</ref>


===Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Cyclopropyl R-Group===
==See Also==
 
*[[Isochorismate pyruvate lyase|Isochorismate pyruvate lyase]]
 
== References ==
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[[Category: Large Structures]]
{{ABSTRACT_PUBMED_22607697}}
 
==About this Structure==
[[3rv8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RV8 OCA].
 
==Reference==
<ref group="xtra">PMID:022607697</ref><references group="xtra"/>
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Bulloch, E M.M.]]
[[Category: Bulloch EMM]]
[[Category: Chi, G.]]
[[Category: Chi G]]
[[Category: Lott, J S.]]
[[Category: Lott JS]]
[[Category: Manos-Turvey, A.]]
[[Category: Manos-Turvey A]]
[[Category: Payne, R J.]]
[[Category: Payne RJ]]
[[Category: TBSGC, TB Structural Genomics Consortium.]]
[[Category: Chorismate binding]]
[[Category: Isomerase-isomerase inhibitor complex]]
[[Category: Salicylate synthase]]
[[Category: Structural genomic]]
[[Category: Tb structural genomics consortium]]
[[Category: Tbsgc]]

Latest revision as of 11:36, 20 March 2024

Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Cyclopropyl R-GroupStructure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Cyclopropyl R-Group

Structural highlights

3rv8 is a 4 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.29Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MBTI_MYCTU Mediates the production of salicylate from chorismate via an isochorismate intermediate. Presents both isochorismate synthase and isochorismate-pyruvate lyase activities. Salycilate is the starter unit in the production of the virulence-conferring salicylate-based siderophore mycobactin.[1]

See Also

References

  1. ↑ Harrison AJ, Yu M, Gardenborg T, Middleditch M, Ramsay RJ, Baker EN, Lott JS. The structure of MbtI from Mycobacterium tuberculosis, the first enzyme in the biosynthesis of the siderophore mycobactin, reveals it to be a salicylate synthase. J Bacteriol. 2006 Sep;188(17):6081-91. PMID:16923875 doi:http://dx.doi.org/188/17/6081

3rv8, resolution 2.29Å

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