2eyq: Difference between revisions

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-[[Image:2eyq.png|left|200px]]
-<!--
+==Crystal structure of Escherichia coli transcription-repair coupling factor==
-The line below this paragraph, containing "STRUCTURE_2eyq", creates the "Structure Box" on the page.
+<StructureSection load='2eyq' size='340' side='right'caption='[[2eyq]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2eyq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EYQ FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_2eyq|  PDB=2eyq  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eyq OCA], [https://pdbe.org/2eyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eyq RCSB], [https://www.ebi.ac.uk/pdbsum/2eyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eyq ProSAT]</span></td></tr>
+</table>
-===Crystal structure of Escherichia coli transcription-repair coupling factor===
+== Function ==
+[https://www.uniprot.org/uniprot/MFD_ECOLI MFD_ECOLI] Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site. Can also dissociate RNAP that is blocked by low concentration of nucleoside triphosphates or by physical obstruction, such as bound proteins. In addition, can rescue arrested complexes by promoting forward translocation. Has ATPase activity, which is required for removal of stalled RNAP, but seems to lack helicase activity. May act through a translocase activity that rewinds upstream DNA, leading either to translocation or to release of RNAP when the enzyme active site can not continue elongation.<ref>PMID:8465200</ref> <ref>PMID:7876261</ref> <ref>PMID:7876262</ref> <ref>PMID:12086674</ref> <ref>PMID:19700770</ref>
+== Evolutionary Conservation ==
-<!--
+[[Image:Consurf_key_small.gif|200px|right]]
-The line below this paragraph, {{ABSTRACT_PUBMED_16469698}}, adds the Publication Abstract to the page
+Check<jmol>
-(as it appears on PubMed at http://www.pubmed.gov), where 16469698 is the PubMed ID number.
+  <jmolCheckbox>
--->
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ey/2eyq_consurf.spt"</scriptWhenChecked>
-{{ABSTRACT_PUBMED_16469698}}
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
-==About this Structure==
+  </jmolCheckbox>
-[[2eyq]] is a 2 chain structure of [[Transcription-repair coupling factor]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYQ OCA].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eyq ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Transcription-repair coupling factor|Transcription-repair coupling factor]]
+*[[Transcription-repair coupling factor 3D structures|Transcription-repair coupling factor 3D structures]]
-*[[User:Wayne Decatur|User:Wayne Decatur]]
+== References ==
+<references/>
-==Reference==
+__TOC__
-<ref group="xtra">PMID:016469698</ref><references group="xtra"/>
+</StructureSection>
 [[Category: Escherichia coli]]
-[[Category: Darst, S A.]]
+[[Category: Large Structures]]
-[[Category: Deaconescu, A M.]]
+[[Category: Darst SA]]
-[[Category: Hydrolase]]
+[[Category: Deaconescu AM]]
-[[Category: Mfd]]
-[[Category: Sf2 atpase]]