2dnc: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2dnc.jpg|left|200px]]<br /><applet load="2dnc" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="2dnc" />
-'''Solution Structure of RSGI RUH-054, a lipoyl domain from human 2-oxoacid dehydrogenase'''<br />
-==Disease==
+==Solution Structure of RSGI RUH-054, a lipoyl domain from human 2-oxoacid dehydrogenase==
-Known disease associated with this structure: Lacticacidemia due to PDX1 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=608769 608769]]
+<StructureSection load='2dnc' size='340' side='right'caption='[[2dnc]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2dnc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DNC FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dnc OCA], [https://pdbe.org/2dnc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dnc RCSB], [https://www.ebi.ac.uk/pdbsum/2dnc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dnc ProSAT], [https://www.topsan.org/Proteins/RSGI/2dnc TOPSAN]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/ODPX_HUMAN ODPX_HUMAN] Defects in PDHX are the cause of pyruvate dehydrogenase E3-binding protein deficiency (PDHXD) [MIM:[https://omim.org/entry/245349 245349].<ref>PMID:9399911</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/ODPX_HUMAN ODPX_HUMAN] Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dn/2dnc_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dnc ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-DNC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNC OCA].
+*[[Pyruvate dehydrogenase 3D structures|Pyruvate dehydrogenase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Hayashi, F.]]
+[[Category: Hayashi F]]
-[[Category: Hirota, H.]]
+[[Category: Hirota H]]
-[[Category: Kurosaki, C.]]
+[[Category: Kurosaki C]]
-[[Category: Momen, A.Z.M.Ruhul.]]
+[[Category: Ruhul Momen AZM]]
-[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
+[[Category: Yokoyama S]]
-[[Category: Yokoyama, S.]]
+[[Category: Yoshida M]]
-[[Category: Yoshida, M.]]
-[[Category: 2-oxoacid dehydrogenase]]
-[[Category: lipoic acid]]
-[[Category: lipoyl domain]]
-[[Category: national project on protein structural and functional analyses]]
-[[Category: nppsfa]]
-[[Category: riken structural genomics/proteomics initiative]]
-[[Category: rsgi]]
-[[Category: structural genomics]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:21:28 2008''