3vql: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:3vql.jpg|left|200px]]
-<!--
+==Small heat shock protein hsp14.0 of C-terminal deletion variant==
-The line below this paragraph, containing "STRUCTURE_3vql", creates the "Structure Box" on the page.
+<StructureSection load='3vql' size='340' side='right'caption='[[3vql]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3vql]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfurisphaera_tokodaii_str._7 Sulfurisphaera tokodaii str. 7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VQL FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vql OCA], [https://pdbe.org/3vql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vql RCSB], [https://www.ebi.ac.uk/pdbsum/3vql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vql ProSAT]</span></td></tr>
-{{STRUCTURE_3vql|  PDB=3vql  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q970D9_SULTO Q970D9_SULTO]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The small heat shock proteins (sHsps), which are widely found in all domains of life, bind and stabilize denatured proteins to prevent aggregation. The sHsps exist as large oligomers that are composed of 9-40 subunits and control their chaperone activity by the transition of the oligomeric state. Though the oligomeric transition is important for the biological function of most sHsps, atomic details have not been elucidated. Here, we report crystal structures in both the 24-meric and dimeric states for an sHsp, StHsp14.0 from Sulfolobus tokodaii, in order to reveal changes upon the oligomeric transition. The results indicate that StHsp14.0 forms a spherical 24-mer with a diameter of 115 A. The diameter is defined by the inter-monomer angle in the dimer. The dimer structure in the dimeric state shows only small differences from that in the 24-meric state. Some significant differences are exclusively observed at the binding site for the C-terminus. Although a dimer has four interactive sites with neighboring dimers, the weakness of the respective interactions is indicated from the size-exclusion chromatography. The small structural changes imply an activation mechanism mediated by multiple weak interactions.
-===Small heat shock protein hsp14.0 of C-terminal deletion variant===
+Structural Studies on the Oligomeric Transition of a Small Heat Shock Protein, StHsp14.0.,Hanazono Y, Takeda K, Yohda M, Miki K J Mol Biol. 2012 May 18. PMID:22613762<ref>PMID:22613762</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3vql" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_22613762}}, adds the Publication Abstract to the page
+*[[Heat Shock Protein structures|Heat Shock Protein structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 22613762 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_22613762}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-[[3vql]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VQL OCA].
+[[Category: Sulfurisphaera tokodaii str. 7]]
+[[Category: Hanazono Y]]
-==Reference==
+[[Category: Miki K]]
-<ref group="xtra">PMID:022613762</ref><references group="xtra"/>
+[[Category: Takeda K]]
-[[Category: Sulfolobus tokodaii]]
-[[Category: Hanazono, Y.]]
-[[Category: Miki, K.]]
-[[Category: Takeda, K.]]
-[[Category: Alpha-crystallin domain]]
-[[Category: Chaperone]]