2ltp: Difference between revisions
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==Solution structure of the SANT2 domain of the human nuclear receptor corepressor 2 (NCoR2), Northeast Structural Genomics Consortium (NESG) target ID HR4636E== | |||
<StructureSection load='2ltp' size='340' side='right'caption='[[2ltp]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2ltp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LTP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LTP FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ltp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ltp OCA], [https://pdbe.org/2ltp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ltp RCSB], [https://www.ebi.ac.uk/pdbsum/2ltp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ltp ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. | |||
==See Also== | |||
*[[Nuclear receptor corepressor|Nuclear receptor corepressor]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith C]] | |||
[[Category: Bellanda M]] | |||
[[Category: Garcia M]] | |||
[[Category: Houliston S]] | |||
[[Category: Lemak A]] | |||
[[Category: Min J]] | |||
[[Category: Montecchio M]] | |||
[[Category: Montelione GT]] | |||
[[Category: Xu C]] | |||
[[Category: Yee A]] | |||
Latest revision as of 08:51, 15 May 2024
Solution structure of the SANT2 domain of the human nuclear receptor corepressor 2 (NCoR2), Northeast Structural Genomics Consortium (NESG) target ID HR4636ESolution structure of the SANT2 domain of the human nuclear receptor corepressor 2 (NCoR2), Northeast Structural Genomics Consortium (NESG) target ID HR4636E
Structural highlights
FunctionNCOR2_HUMAN Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. See Also |
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