4fbz: Difference between revisions
New page: '''Unreleased structure''' The entry 4fbz is ON HOLD Authors: Kouyama, K. Description: crystal structure of deltarhodopsin from Haloterrigena thermotolerans |
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==Crystal structure of deltarhodopsin from Haloterrigena thermotolerans== | |||
<StructureSection load='4fbz' size='340' side='right'caption='[[4fbz]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4fbz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haloterrigena_thermotolerans Haloterrigena thermotolerans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FBZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FBZ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=22B:BACTERIORUBERIN'>22B</scene>, <scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=L2P:2,3-DI-PHYTANYL-GLYCEROL'>L2P</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SQL:(6E,10E,14E,18E)-2,6,10,15,19,23-HEXAMETHYLTETRACOSA-2,6,10,14,18,22-HEXAENE'>SQL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fbz OCA], [https://pdbe.org/4fbz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fbz RCSB], [https://www.ebi.ac.uk/pdbsum/4fbz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fbz ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/I4DST7_9EURY I4DST7_9EURY] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Deltarhodopsin, a new member of the microbial rhodopsin family, functions as a light-driven proton pump. Here, we report the three-dimensional structure of deltarhodopsin (dR3) from Haloterrigena thermotolerans at 2.7 A resolution. A crystal belonging to space group R32 (a, b = 111.71 A, c = 198.25 A) was obtained by the membrane fusion method. In this crystal, dR3 forms a trimeric structure as observed for bacteriorhodopsin (bR). Structural comparison of dR with bR showed that the inner part (the proton release and uptake pathways) is highly conserved. Meanwhile, residues in the protein-protein contact region are largely altered so that the diameter of the trimeric structure at the cytoplasmic side is noticeably larger in dR3. Unlike bR, dR3 possesses a helical segment at the C-terminal region that fills the space between the AB and EF loops. A significant difference is also seen in the FG loop, which is one residue longer in dR3. Another peculiar property of dR3 is a highly crowded distribution of positively charged residues on the cytoplasmic surface, which may be relevant to a specific interaction with some cytoplasmic component. (c) Proteins 2013;. (c) 2013 Wiley Periodicals, Inc. | |||
Crystal structure of deltarhodopsin-3 from haloterrigena thermotolerans.,Zhang J, Mizuno K, Murata Y, Koide H, Murakami M, Ihara K, Kouyama T Proteins. 2013 Apr 29. doi: 10.1002/prot.24316. PMID:23625688<ref>PMID:23625688</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4fbz" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Bacteriorhodopsin 3D structures|Bacteriorhodopsin 3D structures]] | |||
*[[Rhodopsin 3D structures|Rhodopsin 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Haloterrigena thermotolerans]] | |||
[[Category: Large Structures]] | |||
[[Category: Kouyama T]] | |||