2vzd: Difference between revisions

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-[[Image:2vzd.png|left|200px]]
-<!--
+==Crystal structure of the C-terminal calponin homology domain of alpha parvin in complex with paxillin LD1 motif==
-The line below this paragraph, containing "STRUCTURE_2vzd", creates the "Structure Box" on the page.
+<StructureSection load='2vzd' size='340' side='right'caption='[[2vzd]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2vzd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VZD FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-{{STRUCTURE_2vzd|  PDB=2vzd  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vzd OCA], [https://pdbe.org/2vzd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vzd RCSB], [https://www.ebi.ac.uk/pdbsum/2vzd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vzd ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PARVA_HUMAN PARVA_HUMAN] Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration.<ref>PMID:11331308</ref> <ref>PMID:11134073</ref> <ref>PMID:15284246</ref> <ref>PMID:20393563</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vz/2vzd_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vzd ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The adaptor protein paxillin contains five conserved leucine-rich (LD) motifs that interact with a variety of focal adhesion proteins, such as alpha-parvin. Here, we report the first crystal structure of the C-terminal calponin homology domain (CH(C)) of alpha-parvin at 1.05 A resolution and show that it is able to bind all the LD motifs, with some selectivity for LD1, LD2, and LD4. Cocrystal structures with these LD motifs reveal the molecular details of their interactions with a common binding site on alpha-parvin-CH(C), which is located at the rim of the canonical fold and includes part of the inter-CH domain linker. Surprisingly, this binding site can accommodate LD motifs in two antiparallel orientations. Taken together, these results reveal an unusual degree of binding degeneracy in the paxillin/alpha-parvin system that may facilitate the assembly of dynamic signaling complexes in the cell.
-===Crystal structure of the C-terminal calponin homology domain of alpha parvin in complex with paxillin LD1 motif===
+Structural analysis of the interactions between paxillin LD motifs and alpha-parvin.,Lorenz S, Vakonakis I, Lowe ED, Campbell ID, Noble ME, Hoellerer MK Structure. 2008 Oct 8;16(10):1521-31. PMID:18940607<ref>PMID:18940607</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_18940607}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 2vzd" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 18940607 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_18940607}}
-==About this Structure==
-[[2vzd]] is a 4 chain structure of [[Alpha-parvin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VZD OCA].
 ==See Also==
-*[[Alpha-parvin|Alpha-parvin]]
+*[[Parvin|Parvin]]
+*[[Parvin 3D structures|Parvin 3D structures]]
-==Reference==
+*[[Paxillin|Paxillin]]
-<ref group="xtra">PMID:018940607</ref><references group="xtra"/>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Campbell, I D.]]
+[[Category: Large Structures]]
-[[Category: Hoellerer, M K.]]
+[[Category: Campbell ID]]
-[[Category: Lorenz, S.]]
+[[Category: Hoellerer MK]]
-[[Category: Lowe, E D.]]
+[[Category: Lorenz S]]
-[[Category: Noble, M E.M.]]
+[[Category: Lowe ED]]
-[[Category: Vakonakis, I.]]
+[[Category: Noble MEM]]
-[[Category: Actin-binding]]
+[[Category: Vakonakis I]]
-[[Category: Calponin homology domain]]
-[[Category: Cell adhesion]]
-[[Category: Cell junction]]
-[[Category: Cell membrane]]
-[[Category: Cytoskeleton]]
-[[Category: Ld1 motif]]
-[[Category: Lim domain]]
-[[Category: Membrane]]
-[[Category: Metal-binding]]
-[[Category: Phosphoprotein]]