4drv: Difference between revisions

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[[Image:4drv.png|left|200px]]


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==Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen==
The line below this paragraph, containing "STRUCTURE_4drv", creates the "Structure Box" on the page.
<StructureSection load='4drv' size='340' side='right'caption='[[4drv]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[4drv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rotavirus_sp. Rotavirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DRV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DRV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene></td></tr>
{{STRUCTURE_4drv|  PDB=4drv  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4drv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4drv OCA], [https://pdbe.org/4drv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4drv RCSB], [https://www.ebi.ac.uk/pdbsum/4drv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4drv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q86169_9REOV Q86169_9REOV] Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment.[SAAS:SAAS00136874]  VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.[SAAS:SAAS00136880]


===Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen===
==See Also==
 
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_22504179}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 22504179 is the PubMed ID number.
[[Category: Rotavirus sp]]
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[[Category: Cortes-Penfield NW]]
{{ABSTRACT_PUBMED_22504179}}
[[Category: Crawford SE]]
 
[[Category: Czako R]]
==About this Structure==
[[Category: Estes MK]]
[[4drv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rotavirus_sp. Rotavirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DRV OCA].
[[Category: Hu L]]
 
[[Category: Le Pendu J]]
==Reference==
[[Category: Prasad BVV]]
<ref group="xtra">PMID:022504179</ref><references group="xtra"/>
[[Category: Smith DF]]
[[Category: Rotavirus sp.]]
[[Category: Cortes-Penfield, N W.]]
[[Category: Crawford, S E.]]
[[Category: Czako, R.]]
[[Category: Estes, M K.]]
[[Category: Hu, L.]]
[[Category: Pendu, J Le.]]
[[Category: Prasad, B V.V.]]
[[Category: Smith, D F.]]
[[Category: Cell attachment factor]]
[[Category: Galectin-fold]]
[[Category: Histo blood group antigen]]
[[Category: Otavirus]]
[[Category: Viral protein]]

Latest revision as of 17:43, 14 March 2024

Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigenCell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen

Structural highlights

4drv is a 1 chain structure with sequence from Rotavirus sp.. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.56Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q86169_9REOV Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment.[SAAS:SAAS00136874] VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.[SAAS:SAAS00136880]

See Also

4drv, resolution 1.56Å

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