4e0q: Difference between revisions

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-[[Image:4e0q.png|left|200px]]
-<!--
+==Crystal structure of MPN domain from COP9 signalosome==
-The line below this paragraph, containing "STRUCTURE_4e0q", creates the "Structure Box" on the page.
+<StructureSection load='4e0q' size='340' side='right'caption='[[4e0q]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[4e0q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E0Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E0Q FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-{{STRUCTURE_4e0q|  PDB=4e0q  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e0q OCA], [https://pdbe.org/4e0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e0q RCSB], [https://www.ebi.ac.uk/pdbsum/4e0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e0q ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The COP9 signalosome (CSN) is a multiprotein complex containing eight subunits and is highly conserved from fungi to human. CSN is proposed to widely participate in many physiological processes, including protein degradation, DNA damage response and signal transduction. Among those subunits, only CSN5 and CSN6 belong to JAMM family. CSN5 possesses isopeptidase activity, but CSN6 lacks this ability. Here we report the 2.5A crystal structure of MPN domain from Drosophila melanogaster CSN6. Structural comparison with other MPN domains, along with bioinformation analysis, suggests that MPN domain from CSN6 may serve as a scaffold instead of a metalloprotease. STRUCTURED SUMMARY OF PROTEIN INTERACTIONS: CSN6 and CSN6bind by x-ray crystallography (View interaction) CSN6 and CSN6bind by x ray scattering (View interaction).
-===Crystal structure of MPN domain from COP9 signalosome===
+The crystal structure of the MPN domain from the COP9 signalosome subunit CSN6.,Zhang H, Gao ZQ, Wang WJ, Liu GF, Shtykova EV, Xu JH, Li LF, Su XD, Dong YH FEBS Lett. 2012 Apr 24;586(8):1147-53. Epub 2012 Mar 23. PMID:22575649<ref>PMID:22575649</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 4e0q" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_22575649}}, adds the Publication Abstract to the page
+*[[Signalosome|Signalosome]]
-(as it appears on PubMed at http://www.pubmed.gov), where 22575649 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_22575649}}
+__TOC__
+</StructureSection>
-==About this Structure==
-[[4e0q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E0Q OCA].
-==Reference==
-<ref group="xtra">PMID:022575649</ref><references group="xtra"/>
 [[Category: Drosophila melanogaster]]
-[[Category: Dong, Y H.]]
+[[Category: Large Structures]]
-[[Category: Gao, Z Q.]]
+[[Category: Dong YH]]
-[[Category: Zhang, H.]]
+[[Category: Gao ZQ]]
-[[Category: Unknown function]]
+[[Category: Zhang H]]