4ds0: Difference between revisions

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-[[Image:4ds0.png|left|200px]]
-<!--
+==Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen==
-The line below this paragraph, containing "STRUCTURE_4ds0", creates the "Structure Box" on the page.
+<StructureSection load='4ds0' size='340' side='right'caption='[[4ds0]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[4ds0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rotavirus_sp. Rotavirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DS0 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900132:Blood+group+A+H+type+2+antigen,+beta+anomer'>PRD_900132</scene></td></tr>
-{{STRUCTURE_4ds0|  PDB=4ds0  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ds0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ds0 OCA], [https://pdbe.org/4ds0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ds0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ds0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ds0 ProSAT]</span></td></tr>
+</table>
-===Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen===
+== Function ==
+[https://www.uniprot.org/uniprot/Q86169_9REOV Q86169_9REOV] Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment.[SAAS:SAAS00136874]  VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.[SAAS:SAAS00136880]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_22504179}}, adds the Publication Abstract to the page
+[[Category: Large Structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 22504179 is the PubMed ID number.
+[[Category: Rotavirus sp]]
--->
+[[Category: Cortes-Penfield NW]]
-{{ABSTRACT_PUBMED_22504179}}
+[[Category: Crawford SE]]
+[[Category: Czako R]]
-==About this Structure==
+[[Category: Estes MK]]
-[[4ds0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rotavirus_sp. Rotavirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DS0 OCA].
+[[Category: Hu L]]
+[[Category: Le Pendu J]]
-==Reference==
+[[Category: Prasad BVV]]
-<ref group="xtra">PMID:022504179</ref><references group="xtra"/>
+[[Category: Smith DF]]
-[[Category: Rotavirus sp.]]
-[[Category: Cortes-Penfield, N W.]]
-[[Category: Crawford, S E.]]
-[[Category: Czako, R.]]
-[[Category: Estes, M K.]]
-[[Category: Hu, L.]]
-[[Category: Pendu, J Le.]]
-[[Category: Prasad, B V.V.]]
-[[Category: Smith, D F.]]
-[[Category: Cell attachment factor]]
-[[Category: Galectin-fold]]
-[[Category: Histo blood group antigen]]
-[[Category: Otavirus]]
-[[Category: Viral protein]]