Lipase lid morph: Difference between revisions
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A morph<ref>This is a [[Morphs#Linear_Interpolation|linear interpolation morph]]. The 14-model PDB file is [[Image:Morph-linear-1trh-1lpm.pdb.gz]].</ref> shows the lid opening and closing. | A morph<ref>This is a [[Morphs#Linear_Interpolation|linear interpolation morph]]. The 14-model PDB file is [[Image:Morph-linear-1trh-1lpm.pdb.gz]].</ref> shows the lid opening and closing. | ||
*<scene name='Lipase_lid_morph/Lightseagreen_hinge/2'>Cartoon morph</scene> (<font color='lightseagreen'><b>LID</b></font>). | *<scene name='Lipase_lid_morph/Lightseagreen_hinge/2'>Cartoon morph</scene> (<font color='lightseagreen'><b>LID</b></font>). | ||
*<scene name='Lipase_lid_morph/Lightseagreen_hinge/3'>Spacefilling morph</scene> (<font color='lightseagreen'><b>LID</b></font>, <font color='orange'><b>catalytic triad: Ser209, Glu341, and His449</b></font><ref name='2states1994' />). | *<scene name='Lipase_lid_morph/Lightseagreen_hinge/3'>Spacefilling morph</scene> (<font color='lightseagreen'><b>LID</b></font>, <font color='orange'><b>catalytic triad: Ser209, Glu341, and His449</b></font><ref name='2states1994' />).<br> | ||
{{Template:Button Toggle Animation2}} | |||
When the lid is closed, the enzyme surface is largely {{Template:ColorKey_Polar}}. When the lid opens, a {{Template:ColorKey_Hydrophobic}} pocket is exposed with the catalytic triad in the bottom. | |||
*<scene name='Lipase_lid_morph/Lightseagreen_hinge/5'>Spacefilling morph</scene> ({{Template:ColorKey_Polar}}, {{Template:ColorKey_Hydrophobic}}, <font color='orange'><b>catalytic triad: Ser209, Glu341, and His449</b></font><ref name='2states1994' />). | |||
An alternate morph<ref>This is a rigid body morph based on the superposition in PDB file [[Image:1TRH_1LPM.pdb]]. It is created by the [[Jmol/Storymorph|Storymorph script]] on the fly.</ref> shows a different path between the <scene name='49/493694/Storymorph/1'>same initial and final experimental structures</scene>. The position of the inhibitor in the 1lpm structure is shown throughout; it would clash with the conformation of the lid in the 1trh structures, showing that closed lid and inhibitor binding are mutually exclusive. | |||
<jmol> | |||
<jmolButton> | |||
<script>script "https://proteopedia.org/wiki/images/a/a2/Storymorph.spt"; | |||
domain2 = {(75-85)}; | |||
model 2; | |||
structures = [{1.2}, {1.1}]; | |||
domains = [ | |||
[{protein and not domain2}], | |||
[{domain2}, {(74,86) and *.CA}], | |||
]; | |||
morph_palindrome = 1; | |||
morph(15,structures,domains);</script> | |||
<text>Run alternate morph</text> | |||
</jmolButton> | |||
</jmol> | |||
==See Also== | ==See Also== | ||