4ewp: Difference between revisions
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New page: '''Unreleased structure''' The entry 4ewp is ON HOLD Authors: Pereira, J.H., Goh, E.-B., Keasling, J.D., Beller, H.R., Adams, P.D. Description: Crystal structure of FabH from Micrococc... |
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==Crystal structure of FabH from Micrococcus luteus== | |||
<StructureSection load='4ewp' size='340' side='right'caption='[[4ewp]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4ewp]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Micrococcus_luteus_NCTC_2665 Micrococcus luteus NCTC 2665]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EWP FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.198Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ewp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ewp OCA], [https://pdbe.org/4ewp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ewp RCSB], [https://www.ebi.ac.uk/pdbsum/4ewp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ewp ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/C5CAR9_MICLC C5CAR9_MICLC] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids (By similarity).[HAMAP-Rule:MF_01815] | |||
==See Also== | |||
*[[Acyl carrier protein synthase 3D structures|Acyl carrier protein synthase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Micrococcus luteus NCTC 2665]] | |||
[[Category: Adams PD]] | |||
[[Category: Beller HR]] | |||
[[Category: Goh E-B]] | |||
[[Category: Keasling JD]] | |||
[[Category: Pereira JH]] | |||
Latest revision as of 14:06, 1 March 2024
Crystal structure of FabH from Micrococcus luteusCrystal structure of FabH from Micrococcus luteus
Structural highlights
FunctionC5CAR9_MICLC Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids (By similarity).[HAMAP-Rule:MF_01815] See Also |
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