OspA: Difference between revisions
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< | <StructureSection load='1fj1' size='350' side='right' caption='OspA (magenta and cyan) complex with antibody light chain (grey and pink) and heavy chain (green and yellow) (PDB code [[1fj1]])' scene=''> | ||
== Outer surface protein A (OspA) of the Lyme disease spirochete bacterium == | == Outer surface protein A (OspA) of the Lyme disease spirochete bacterium == | ||
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<scene name='User:Ji_Youn_Park/Loop_1_52/2'>Loop 1</scene> colored red on the 3-D structure, consists of residues 203 to 220. However, a natural variation found on <scene name='User:Ji_Youn_Park/Res208_51/3'>residue 208</scene> colored yellow, of the first loop is a significant limiting factor in the antibody binding. <scene name='User:Ji_Youn_Park/Loop_2_51/3'>Loop 2</scene>, colored purple, consists of residues 224 to 233. And <scene name='User:Ji_Youn_Park/Loop_3_51/4'>Loop 3</scene> colored blue, consists of residues 246 to 257. The remainder of the beta sheets was colored cyan because they did not play any significant role in OspA. This prototype suggests the importance of the three specific loops and their purpose to binding. | <scene name='User:Ji_Youn_Park/Loop_1_52/2'>Loop 1</scene> colored red on the 3-D structure, consists of residues 203 to 220. However, a natural variation found on <scene name='User:Ji_Youn_Park/Res208_51/3'>residue 208</scene> colored yellow, of the first loop is a significant limiting factor in the antibody binding. <scene name='User:Ji_Youn_Park/Loop_2_51/3'>Loop 2</scene>, colored purple, consists of residues 224 to 233. And <scene name='User:Ji_Youn_Park/Loop_3_51/4'>Loop 3</scene> colored blue, consists of residues 246 to 257. The remainder of the beta sheets was colored cyan because they did not play any significant role in OspA. This prototype suggests the importance of the three specific loops and their purpose to binding. | ||
==3D structures== | |||
See [[Outer surface protein]] | |||
== References == | == References == | ||
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Rupprecht, Tobias A. “The Pathogenesis of Lyme Neuroborreliosis: From Infection to Inflammation.” MOL MED. (2008): 205-212. | Rupprecht, Tobias A. “The Pathogenesis of Lyme Neuroborreliosis: From Infection to Inflammation.” MOL MED. (2008): 205-212. | ||
</StructureSection> | |||