2jaj: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2jaj.gif|left|200px]]<br />
-<applet load="2jaj" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="2jaj, resolution 2.00&Aring;" />
-'''DDAH1 COMPLEXED WITH L-257'''<br />
-==About this Structure==
+==DDAH1 complexed with L-257==
-JAJ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with D20 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.18 3.5.3.18]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JAJ OCA]].
+<StructureSection load='2jaj' size='340' side='right'caption='[[2jaj]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2jaj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JAJ FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D20:N~5~-{IMINO[(2-METHOXYETHYL)AMINO]METHYL}-L-ORNITHINE'>D20</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jaj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jaj OCA], [https://pdbe.org/2jaj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jaj RCSB], [https://www.ebi.ac.uk/pdbsum/2jaj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jaj ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DDAH1_HUMAN DDAH1_HUMAN] Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ja/2jaj_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jaj ConSurf].
+<div style="clear:both"></div>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Hara, B.P.O.]]
+[[Category: Leiper JM]]
-[[Category: Leiper, J.M.]]
+[[Category: McDonald NQ]]
-[[Category: Mcdonald, N.Q.]]
+[[Category: Murray-Rust J]]
-[[Category: Murray-Rust, J.]]
+[[Category: O'Hara BP]]
-[[Category: Rossiter, S.]]
+[[Category: Rossiter S]]
-[[Category: Vallance, P.]]
+[[Category: Vallance P]]
-[[Category: D20]]
-[[Category: ddah]]
-[[Category: hydrolase]]
-[[Category: nitric oxide synthase inhibitor]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 16:00:39 2007''