4eup: Difference between revisions

Latest revision as of 18:09, 14 March 2024

The complex between TCR JKF6 and human Class I MHC HLA-A2 presenting the MART-1(27-35)(A27L) peptideThe complex between TCR JKF6 and human Class I MHC HLA-A2 presenting the MART-1(27-35)(A27L) peptide

Structural highlights

4eup is a 10 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.88Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MAR1_HUMAN Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.^[1] ^[2]

References

↑ Hoashi T, Watabe H, Muller J, Yamaguchi Y, Vieira WD, Hearing VJ. MART-1 is required for the function of the melanosomal matrix protein PMEL17/GP100 and the maturation of melanosomes. J Biol Chem. 2005 Apr 8;280(14):14006-16. Epub 2005 Jan 28. PMID:15695812 doi:10.1074/jbc.M413692200
↑ Giordano F, Bonetti C, Surace EM, Marigo V, Raposo G. The ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and composition. Hum Mol Genet. 2009 Dec 1;18(23):4530-45. doi: 10.1093/hmg/ddp415. Epub 2009 Aug , 28. PMID:19717472 doi:10.1093/hmg/ddp415

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OCA

[1] Hoashi T, Watabe H, Muller J, Yamaguchi Y, Vieira WD, Hearing VJ. MART-1 is required for the function of the melanosomal matrix protein PMEL17/GP100 and the maturation of melanosomes. J Biol Chem. 2005 Apr 8;280(14):14006-16. Epub 2005 Jan 28. PMID:15695812 doi:10.1074/jbc.M413692200

[2] Giordano F, Bonetti C, Surace EM, Marigo V, Raposo G. The ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and composition. Hum Mol Genet. 2009 Dec 1;18(23):4530-45. doi: 10.1093/hmg/ddp415. Epub 2009 Aug , 28. PMID:19717472 doi:10.1093/hmg/ddp415

[1]

[2]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4eup is ON HOLD
+==The complex between TCR JKF6 and human Class I MHC HLA-A2 presenting the MART-1(27-35)(A27L) peptide==
+<StructureSection load='4eup' size='340' side='right'caption='[[4eup]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4eup]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EUP FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.88&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eup OCA], [https://pdbe.org/4eup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eup RCSB], [https://www.ebi.ac.uk/pdbsum/4eup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eup ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MAR1_HUMAN MAR1_HUMAN] Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.<ref>PMID:15695812</ref> <ref>PMID:19717472</ref>
-Authors: Hossain, M., Baker, B.M.
+==See Also==
+*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
-Description: THE COMPLEX BETWEEN TCR JKF6 AND HUMAN CLASS I MHC HLA-A2 PRESENTING THE MART-1(27-35)(A27L) PEPTIDE
+*[[MHC 3D structures|MHC 3D structures]]
+*[[MHC I 3D structures|MHC I 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Baker BM]]
+[[Category: Hossain M]]

4eup: Difference between revisions

Latest revision as of 18:09, 14 March 2024

The complex between TCR JKF6 and human Class I MHC HLA-A2 presenting the MART-1(27-35)(A27L) peptideThe complex between TCR JKF6 and human Class I MHC HLA-A2 presenting the MART-1(27-35)(A27L) peptide

Structural highlights

Function

See Also

References

Contents

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4eup: Difference between revisions

Latest revision as of 18:09, 14 March 2024

The complex between TCR JKF6 and human Class I MHC HLA-A2 presenting the MART-1(27-35)(A27L) peptideThe complex between TCR JKF6 and human Class I MHC HLA-A2 presenting the MART-1(27-35)(A27L) peptide

Structural highlights

Function

See Also

References

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