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< | ==Models for the T. thermophilus ribosome recycling factor and the E. coli elongation factor G bound to the E. coli post-termination complex== | ||
<SX load='3j0e' size='340' side='right' viewer='molstar' caption='[[3j0e]], [[Resolution|resolution]] 9.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3j0e]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J0E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J0E FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 9.9Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j0e OCA], [https://pdbe.org/3j0e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j0e RCSB], [https://www.ebi.ac.uk/pdbsum/3j0e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j0e ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RS12_ECOLI RS12_ECOLI] With S4 and S5 plays an important role in translational accuracy.[HAMAP-Rule:MF_00403_B] Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity).[HAMAP-Rule:MF_00403_B] Cryo-EM studies suggest that S12 contacts the EF-Tu bound tRNA in the A-site during codon-recognition. This contact is most likely broken as the aminoacyl-tRNA moves into the peptidyl transferase center in the 50S subunit.[HAMAP-Rule:MF_00403_B] | |||
=== | ==See Also== | ||
*[[Elongation factor 3D structures|Elongation factor 3D structures]] | |||
*[[Ribosomal protein S12|Ribosomal protein S12]] | |||
*[[Ribosome recycling factor|Ribosome recycling factor]] | |||
__TOC__ | |||
</SX> | |||
[[ | |||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Large Structures]] | |||
[[Category: Thermus thermophilus]] | [[Category: Thermus thermophilus]] | ||
[[Category: Agrawal | [[Category: Agrawal RK]] | ||
[[Category: Iwakura | [[Category: Iwakura N]] | ||
[[Category: Kaji | [[Category: Kaji A]] | ||
[[Category: Kaji | [[Category: Kaji H]] | ||
[[Category: Shaikh | [[Category: Shaikh TR]] | ||
[[Category: Yokoyama | [[Category: Yokoyama T]] | ||
Latest revision as of 13:09, 21 February 2024
Models for the T. thermophilus ribosome recycling factor and the E. coli elongation factor G bound to the E. coli post-termination complexModels for the T. thermophilus ribosome recycling factor and the E. coli elongation factor G bound to the E. coli post-termination complex
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