3vd2: Difference between revisions

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-[[Image:3vd2.jpg|left|200px]]
-<!--
+==structure of p73 DNA binding domain tetramer modulates p73 transactivation==
-The line below this paragraph, containing "STRUCTURE_3vd2", creates the "Structure Box" on the page.
+<StructureSection load='3vd2' size='340' side='right'caption='[[3vd2]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3vd2]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VD2 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_3vd2|  PDB=3vd2  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vd2 OCA], [https://pdbe.org/3vd2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vd2 RCSB], [https://www.ebi.ac.uk/pdbsum/3vd2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vd2 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The transcription factor p73 triggers developmental pathways and overlaps stress-induced p53 transcriptional pathways. How p53-family response elements determine and regulate transcriptional specificity remains an unsolved problem. In this work, we have determined the first crystal structures of p73 DNA-binding domain tetramer bound to response elements with spacers of different length. The structure and function of the adaptable tetramer are determined by the distance between two half-sites. The structures with zero and one base-pair spacers show compact p73 DNA-binding domain tetramers with large tetramerization interfaces; a two base-pair spacer results in DNA unwinding and a smaller tetramerization interface, whereas a four base-pair spacer hinders tetramerization. Functionally, p73 is more sensitive to spacer length than p53, with one base-pair spacer reducing 90% of transactivation activity and longer spacers reducing transactivation to basal levels. Our results establish the quaternary structure of the p73 DNA-binding domain required as a scaffold to promote transactivation.
-===structure of p73 DNA binding domain tetramer modulates p73 transactivation===
+Structure of p73 DNA-binding domain tetramer modulates p73 transactivation.,Ethayathulla AS, Tse PW, Monti P, Nguyen S, Inga A, Fronza G, Viadiu H Proc Natl Acad Sci U S A. 2012 Apr 2. PMID:22474346<ref>PMID:22474346</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3vd2" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_22474346}}, adds the Publication Abstract to the page
+*[[P73|P73]]
-(as it appears on PubMed at http://www.pubmed.gov), where 22474346 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_22474346}}
+__TOC__
+</StructureSection>
-==About this Structure==
-[[3vd2]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VD2 OCA].
-==Reference==
-<ref group="xtra">PMID:022474346</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Ethayathulla, A S.]]
+[[Category: Large Structures]]
-[[Category: Nguyen, S.]]
+[[Category: Ethayathulla AS]]
-[[Category: Tse, P W.]]
+[[Category: Nguyen S]]
-[[Category: Viadiu, H.]]
+[[Category: Tse PW]]
-[[Category: Antitumor protein-dna complex]]
+[[Category: Viadiu H]]
-[[Category: Beta-immunoglobulin-like fold]]
-[[Category: Dna]]
-[[Category: Protein dna complex]]
-[[Category: Tumour suppressor]]