3vjc: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:3vjc.jpg|left|200px]]
-<!--
+==Crystal structure of the human squalene synthase in complex with zaragozic acid A==
-The line below this paragraph, containing "STRUCTURE_3vjc", creates the "Structure Box" on the page.
+<StructureSection load='3vjc' size='340' side='right'caption='[[3vjc]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3vjc]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VJC FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZGA:ZARAGOZIC+ACID+A'>ZGA</scene></td></tr>
-{{STRUCTURE_3vjc|  PDB=3vjc  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vjc OCA], [https://pdbe.org/3vjc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vjc RCSB], [https://www.ebi.ac.uk/pdbsum/3vjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vjc ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/FDFT_HUMAN FDFT_HUMAN]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Zaragozic acids (ZAs) belong to a family of fungal metabolites with nanomolar inhibitory activity toward squalene synthase (SQS). The enzyme catalyzes the committed step of sterol synthesis and has attracted attention as a potential target for antilipogenic and antiinfective therapies. Here, we have determined the structure of ZA-A complexed with human SQS. ZA-A binding induces a local conformational change in the substrate binding site, and its C-6 acyl group also extends over to the cofactor binding cavity. In addition, ZA-A effectively inhibits a homologous bacterial enzyme, dehydrosqualene synthase (CrtM), which synthesizes the precursor of staphyloxanthin in Staphylococcus aureus to cope with oxidative stress. Size reduction at Tyr(248) in CrtM further increases the ZA-A binding affinity, and it reveals a similar overall inhibitor binding mode to that of human SQS/ZA-A except for the C-6 acyl group. These structures pave the way for further improving selectivity and development of a new generation of anticholesterolemic and antimicrobial inhibitors.
-===Crystal structure of the human squalene synthase in complex with zaragozic acid A===
+Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase.,Liu CI, Jeng WY, Chang WJ, Ko TP, Wang AH J Biol Chem. 2012 May 25;287(22):18750-7. Epub 2012 Apr 3. PMID:22474324<ref>PMID:22474324</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3vjc" style="background-color:#fffaf0;"></div>
-==About this Structure==
+==See Also==
-[[3vjc]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VJC OCA].
+*[[Squalene synthase|Squalene synthase]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Squalene synthase]]
+[[Category: Large Structures]]
-[[Category: Chang, W J.]]
+[[Category: Chang WJ]]
-[[Category: Jeng, W Y.]]
+[[Category: Jeng WY]]
-[[Category: Ko, T P.]]
+[[Category: Ko TP]]
-[[Category: Liu, C I.]]
+[[Category: Liu CI]]
-[[Category: Wang, A H.J.]]
+[[Category: Wang AHJ]]
-[[Category: Cholesterol biosynthesis]]
-[[Category: Farnesyl-diphosphate farnesyltransferase]]
-[[Category: Head-to-head synthase]]
-[[Category: Oxidoreductase]]
-[[Category: Transferase-transferase inhibitor complex]]