4dbs: Difference between revisions

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[[Image:4dbs.png|left|200px]]


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==Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) in complex with NADP+ and 3'-[(4-nitronaphthalen-1-yl)amino]benzoic acid==
The line below this paragraph, containing "STRUCTURE_4dbs", creates the "Structure Box" on the page.
<StructureSection load='4dbs' size='340' side='right'caption='[[4dbs]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[4dbs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DBS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DBS FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.852&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0HV:3-[(4-NITRONAPHTHALEN-1-YL)AMINO]BENZOIC+ACID'>0HV</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
{{STRUCTURE_4dbs|  PDB=4dbs  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dbs OCA], [https://pdbe.org/4dbs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dbs RCSB], [https://www.ebi.ac.uk/pdbsum/4dbs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dbs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.


===Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) in complex with NADP+ and 3'-[(4-nitronaphthalen-1-yl)amino]benzoic acid===
==See Also==
 
*[[Prostaglandin F synthase 3D structures|Prostaglandin F synthase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
[[4dbs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DBS OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Chen, M.]]
[[Category: Large Structures]]
[[Category: Christianson, D W.]]
[[Category: Chen M]]
[[Category: Penning, T M.]]
[[Category: Christianson DW]]
[[Category: Winkler, J D.]]
[[Category: Penning TM]]
[[Category: Akr1c3 selective inhibitor]]
[[Category: Winkler JD]]
[[Category: Castrate resistant prostate cancer]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
[[Category: Steroid metabolism]]
[[Category: Tim barrel]]

Latest revision as of 17:30, 14 March 2024

Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) in complex with NADP+ and 3'-[(4-nitronaphthalen-1-yl)amino]benzoic acidCrystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) in complex with NADP+ and 3'-[(4-nitronaphthalen-1-yl)amino]benzoic acid

Structural highlights

4dbs is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.852Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

AK1C3_HUMAN Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.

See Also

4dbs, resolution 1.85Å

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