3miw: Difference between revisions

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[[Image:3miw.png|left|200px]]


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==Crystal Structure of Rotavirus NSP4==
The line below this paragraph, containing "STRUCTURE_3miw", creates the "Structure Box" on the page.
<StructureSection load='3miw' size='340' side='right'caption='[[3miw]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3miw]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_rotavirus_G4_strain_St._Thomas_3 Human rotavirus G4 strain St. Thomas 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MIW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MIW FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
{{STRUCTURE_3miw|  PDB=3miw  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3miw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3miw OCA], [https://pdbe.org/3miw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3miw RCSB], [https://www.ebi.ac.uk/pdbsum/3miw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3miw ProSAT]</span></td></tr>
 
</table>
===Crystal Structure of Rotavirus NSP4===
== Function ==
 
[https://www.uniprot.org/uniprot/NSP4_ROTHT NSP4_ROTHT] Involved in virus morphogenesis. Functions as a receptor for the immature double-layered inner capsid particle (ICP) which transiently buds into the lumen of the rough endoplasmic reticulum during viral maturation (By similarity).  Enterotoxin that causes a phospholipase C-dependent elevation of the intracellular calcium concentration in host intestinal mucosa cells. Increased concentration of intracellular calcium disrupts the cytoskeleton and the tight junctions, raising the paracellular permeability. Potentiates chloride ion secretion through a calcium ion-dependent signaling pathway, inducing age-dependent diarrhea. To perform this enterotoxigenic role in vivo, NSP4 is probably released from infected enterocytes in a soluble form capable of diffusing within the intestinal lumen and interacting with the plasma membrane receptors on neighboring epithelial cells. Possible receptors for NSP4 are alpha-1/beta-1 and alpha-2/beta-1 integrin heterodimers (By similarity).
 
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</StructureSection>
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[[Category: Human rotavirus G4 strain St. Thomas 3]]
(as it appears on PubMed at http://www.pubmed.gov), where 22194333 is the PubMed ID number.
[[Category: Large Structures]]
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[[Category: Chacko AR]]
{{ABSTRACT_PUBMED_22194333}}
[[Category: Dodson EJ]]
 
[[Category: Rao DC]]
==About this Structure==
[[Category: Read RJ]]
[[3miw]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Rotavirus_g4 Rotavirus g4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MIW OCA].  
[[Category: Suguna K]]
 
==Reference==
<ref group="xtra">PMID:022194333</ref><references group="xtra"/>
[[Category: Rotavirus g4]]
[[Category: Chacko, A R.]]
[[Category: Dodson, E J.]]
[[Category: Rao, D C.]]
[[Category: Read, R J.]]
[[Category: Suguna, K.]]
[[Category: Non structural protein]]
[[Category: Nsp4]]
[[Category: Pentameric coiled coil]]
[[Category: Rotavirus enterotoxin]]
[[Category: Viral protein]]
[[Category: Virulence]]

Latest revision as of 11:48, 7 February 2024

Crystal Structure of Rotavirus NSP4Crystal Structure of Rotavirus NSP4

Structural highlights

3miw is a 10 chain structure with sequence from Human rotavirus G4 strain St. Thomas 3. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NSP4_ROTHT Involved in virus morphogenesis. Functions as a receptor for the immature double-layered inner capsid particle (ICP) which transiently buds into the lumen of the rough endoplasmic reticulum during viral maturation (By similarity). Enterotoxin that causes a phospholipase C-dependent elevation of the intracellular calcium concentration in host intestinal mucosa cells. Increased concentration of intracellular calcium disrupts the cytoskeleton and the tight junctions, raising the paracellular permeability. Potentiates chloride ion secretion through a calcium ion-dependent signaling pathway, inducing age-dependent diarrhea. To perform this enterotoxigenic role in vivo, NSP4 is probably released from infected enterocytes in a soluble form capable of diffusing within the intestinal lumen and interacting with the plasma membrane receptors on neighboring epithelial cells. Possible receptors for NSP4 are alpha-1/beta-1 and alpha-2/beta-1 integrin heterodimers (By similarity).

3miw, resolution 2.50Å

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