3ffl: Difference between revisions

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[[Image:3ffl.png|left|200px]]


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==Crystal Structure of the N-terminal Domain of Anaphase-Promoting Complex Subunit 7==
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<StructureSection load='3ffl' size='340' side='right'caption='[[3ffl]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3ffl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FFL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ffl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffl OCA], [https://pdbe.org/3ffl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ffl RCSB], [https://www.ebi.ac.uk/pdbsum/3ffl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ffl ProSAT]</span></td></tr>
{{STRUCTURE_3ffl|  PDB=3ffl  |  SCENE=  }}
</table>
 
== Function ==
===Crystal Structure of the N-terminal Domain of Anaphase-Promoting Complex Subunit 7===
[https://www.uniprot.org/uniprot/APC7_HUMAN APC7_HUMAN] Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.<ref>PMID:18485873</ref>  
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ffl ConSurf].
[[3ffl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFL OCA].  
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== References ==
==Reference==
<references/>
<ref group="xtra">PMID:019091741</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Han, D.]]
[[Category: Large Structures]]
[[Category: Kim, K.]]
[[Category: Han D]]
[[Category: Kim, Y.]]
[[Category: Kim K]]
[[Category: Cell cycle]]
[[Category: Kim Y]]
[[Category: Cell division]]
[[Category: Helis-turn-helix]]
[[Category: Mitosis]]
[[Category: Tetratricopeptide repeat motif]]
[[Category: Tpr repeat]]
[[Category: Ubl conjugation pathway]]

Latest revision as of 22:20, 29 May 2024

Crystal Structure of the N-terminal Domain of Anaphase-Promoting Complex Subunit 7Crystal Structure of the N-terminal Domain of Anaphase-Promoting Complex Subunit 7

Structural highlights

3ffl is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

APC7_HUMAN Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Jin L, Williamson A, Banerjee S, Philipp I, Rape M. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. Cell. 2008 May 16;133(4):653-65. doi: 10.1016/j.cell.2008.04.012. PMID:18485873 doi:http://dx.doi.org/10.1016/j.cell.2008.04.012

3ffl, resolution 2.50Å

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