4edy: Difference between revisions
New page: '''Unreleased structure''' The entry 4edy is ON HOLD Authors: Day, J.E., Thorarensen, A., Trujillo, J.I. Description: Crystal structure of hH-PGDS with water displacing inhibitor |
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==Crystal structure of hH-PGDS with water displacing inhibitor== | |||
<StructureSection load='4edy' size='340' side='right'caption='[[4edy]], [[Resolution|resolution]] 1.72Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4edy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EDY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EDY FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9PQ:4-[2-(HYDROXYMETHYL)NAPHTHALEN-1-YL]-N-[2-(MORPHOLIN-4-YL)ETHYL]BENZAMIDE'>9PQ</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4edy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4edy OCA], [https://pdbe.org/4edy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4edy RCSB], [https://www.ebi.ac.uk/pdbsum/4edy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4edy ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HPGDS_HUMAN HPGDS_HUMAN] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10824118</ref> <ref>PMID:11672424</ref> <ref>PMID:9425264</ref> <ref>PMID:9353279</ref> <ref>PMID:12627223</ref> <ref>PMID:15113825</ref> <ref>PMID:16547010</ref> <ref>PMID:19939518</ref> | |||
==See Also== | |||
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Day JE]] | |||
[[Category: Kiefer JR]] | |||
[[Category: Thorarensen A]] | |||
[[Category: Trujillo JI]] | |||