1hlm: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1hlm.jpg|left|200px]]<br /><applet load="1hlm" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="1hlm, resolution 2.9&Aring;" />
-'''AMINO ACID SEQUENCE OF A GLOBIN FROM THE SEA CUCUMBER CAUDINA (MOLPADIA) ARENICOLA'''<br />
-==Overview==
+==AMINO ACID SEQUENCE OF A GLOBIN FROM THE SEA CUCUMBER CAUDINA (MOLPADIA) ARENICOLA==
-Coelomic cells from the sea cucumber Caudina (Molpadia) arenicola contain, four major globins, A, B, C and D. The hemoglobins from this organism show, unusual ligand-linked dissociation properties. The complete amino acid, sequence of the D globin has been established. It is N-acetylated, consists of 158 residues and has a 10 amino acid N-terminal extension, similar to that found in some other invertebrate globins. The C. arenicola, D globin has an equal sequence identity (28%) with both alpha and beta, human globins and as anticipated, is more closely related to these, vertebrate proteins than are molluscan globins. The C. arenicola D globin, shows a 59% identity with the globin I from the sea cucumber Paracaudina, chilensis. The availability of the C. arenicola D globin sequence will aid, the X-ray analysis of this protein and facilitate an understanding of the, changes in subunit interactions that occur with cooperative ligand, binding.
+<StructureSection load='1hlm' size='340' side='right'caption='[[1hlm]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1hlm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Molpadia_arenicola Molpadia arenicola]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HLM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HLM FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hlm OCA], [https://pdbe.org/1hlm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hlm RCSB], [https://www.ebi.ac.uk/pdbsum/1hlm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hlm ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GLBD_MOLAR GLBD_MOLAR]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hl/1hlm_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hlm ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Coelomic cells from the sea cucumber Caudina (Molpadia) arenicola contain four major globins, A, B, C and D. The hemoglobins from this organism show unusual ligand-linked dissociation properties. The complete amino acid sequence of the D globin has been established. It is N-acetylated, consists of 158 residues and has a 10 amino acid N-terminal extension similar to that found in some other invertebrate globins. The C. arenicola D globin has an equal sequence identity (28%) with both alpha and beta human globins and as anticipated, is more closely related to these vertebrate proteins than are molluscan globins. The C. arenicola D globin shows a 59% identity with the globin I from the sea cucumber Paracaudina chilensis. The availability of the C. arenicola D globin sequence will aid the X-ray analysis of this protein and facilitate an understanding of the changes in subunit interactions that occur with cooperative ligand binding.
-==About this Structure==
+Amino acid sequence of a globin from the sea cucumber Caudina (Molpadia) arenicola.,Mauri F, Omnaas J, Davidson L, Whitfill C, Kitto GB Biochim Biophys Acta. 1991 May 30;1078(1):63-7. PMID:2049384<ref>PMID:2049384</ref>
-HLM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermomicrobium_roseum Thermomicrobium roseum] with <scene name='pdbligand=CYN:'>CYN</scene>, <scene name='pdbligand=ACE:'>ACE</scene> and <scene name='pdbligand=HEM:'>HEM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HLM OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-Amino acid sequence of a globin from the sea cucumber Caudina (Molpadia) arenicola., Mauri F, Omnaas J, Davidson L, Whitfill C, Kitto GB, Biochim Biophys Acta. 1991 May 30;1078(1):63-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2049384 2049384]
+</div>
-[[Category: Single protein]]
+<div class="pdbe-citations 1hlm" style="background-color:#fffaf0;"></div>
-[[Category: Thermomicrobium roseum]]
-[[Category: Ernst, S.R.]]
-[[Category: Hackert, M.L.]]
-[[Category: Mitchell, D.T.]]
-[[Category: ACE]]
-[[Category: CYN]]
-[[Category: HEM]]
-[[Category: oxygen transport]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:57:02 2008''
+==See Also==
+*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Molpadia arenicola]]
+[[Category: Ernst SR]]
+[[Category: Hackert ML]]
+[[Category: Mitchell DT]]