3ro6: Difference between revisions

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[[Image:3ro6.png|left|200px]]


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==Crystal structure of Dipeptide Epimerase from Methylococcus capsulatus complexed with Mg ion==
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<StructureSection load='3ro6' size='340' side='right'caption='[[3ro6]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3ro6]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylococcus_capsulatus Methylococcus capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RO6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_3ro6|  PDB=3ro6  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ro6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ro6 OCA], [https://pdbe.org/3ro6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ro6 RCSB], [https://www.ebi.ac.uk/pdbsum/3ro6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ro6 ProSAT]</span></td></tr>
 
</table>
===Crystal structure of Dipeptide Epimerase from Methylococcus capsulatus complexed with Mg ion===
== Function ==
 
[https://www.uniprot.org/uniprot/KRDE_METCA KRDE_METCA] Catalyzes the epimerization of L-Lys-L-Arg to L-Lys-D-Arg. Can also catalyze the epimerization of other cationic dipeptides, such as L-Arg-L-Arg, L-Lys-L-Lys and L-Lys-L-His, but with lower efficiency (in vitro).<ref>PMID:22392983</ref>  
 
== References ==
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<references/>
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[[Category: Large Structures]]
{{ABSTRACT_PUBMED_22392983}}
 
==About this Structure==
[[3ro6]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylococcus_capsulatus Methylococcus capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RO6 OCA].  
 
==Reference==
<ref group="xtra">PMID:022392983</ref><references group="xtra"/>
[[Category: Methylococcus capsulatus]]
[[Category: Methylococcus capsulatus]]
[[Category: Gerlt, J A.]]
[[Category: Gerlt JA]]
[[Category: Lukk, T.]]
[[Category: Lukk T]]
[[Category: Nair, S K.]]
[[Category: Nair SK]]
[[Category: Sakai, A.]]
[[Category: Sakai A]]
[[Category: Song, L.]]
[[Category: Song L]]
[[Category: Isomerase]]
[[Category: Tim barrel]]

Latest revision as of 12:44, 1 March 2024

Crystal structure of Dipeptide Epimerase from Methylococcus capsulatus complexed with Mg ionCrystal structure of Dipeptide Epimerase from Methylococcus capsulatus complexed with Mg ion

Structural highlights

3ro6 is a 6 chain structure with sequence from Methylococcus capsulatus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KRDE_METCA Catalyzes the epimerization of L-Lys-L-Arg to L-Lys-D-Arg. Can also catalyze the epimerization of other cationic dipeptides, such as L-Arg-L-Arg, L-Lys-L-Lys and L-Lys-L-His, but with lower efficiency (in vitro).[1]

References

  1. ↑ Lukk T, Sakai A, Kalyanaraman C, Brown SD, Imker HJ, Song L, Fedorov AA, Fedorov EV, Toro R, Hillerich B, Seidel R, Patskovsky Y, Vetting MW, Nair SK, Babbitt PC, Almo SC, Gerlt JA, Jacobson MP. Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4122-7. Epub 2012 Mar 5. PMID:22392983 doi:10.1073/pnas.1112081109

3ro6, resolution 2.20Å

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