3qbv: Difference between revisions

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[[Image:3qbv.png|left|200px]]


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==Structure of designed orthogonal interaction between CDC42 and nucleotide exchange domains of intersectin==
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<StructureSection load='3qbv' size='340' side='right'caption='[[3qbv]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3qbv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QBV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
{{STRUCTURE_3qbv|  PDB=3qbv  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qbv OCA], [https://pdbe.org/3qbv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qbv RCSB], [https://www.ebi.ac.uk/pdbsum/3qbv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qbv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>  


===Structure of designed orthogonal interaction between CDC42 and nucleotide exchange domains of intersectin===
==See Also==
 
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
 
*[[Intersectin|Intersectin]]
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== References ==
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</StructureSection>
{{ABSTRACT_PUBMED_22403064}}
 
==About this Structure==
[[3qbv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBV OCA].
 
==Reference==
<ref group="xtra">PMID:022403064</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Kapp, G T.]]
[[Category: Large Structures]]
[[Category: Kortemme, T.]]
[[Category: Kapp GT]]
[[Category: Lim, W A.]]
[[Category: Kortemme T]]
[[Category: Remenyi, A.]]
[[Category: Lim WA]]
[[Category: Cell junction]]
[[Category: Remenyi A]]
[[Category: Cell membrane]]
[[Category: Cell projection]]
[[Category: Computationally designed]]
[[Category: Endocytosis]]
[[Category: Gtp-binding]]
[[Category: Gtpase]]
[[Category: Lipoprotein]]
[[Category: Membrane]]
[[Category: Methylation]]
[[Category: Nucleotide exchange]]
[[Category: Nucleotide-binding]]
[[Category: Orthogonal interaction]]
[[Category: Phosphoprotein]]
[[Category: Prenylation]]
[[Category: Protein binding-signaling protein complex]]
[[Category: Sh3 domain]]
[[Category: Synapse]]
[[Category: Synaptosome]]

Latest revision as of 14:40, 14 March 2024

Structure of designed orthogonal interaction between CDC42 and nucleotide exchange domains of intersectinStructure of designed orthogonal interaction between CDC42 and nucleotide exchange domains of intersectin

Structural highlights

3qbv is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.65Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CDC42_HUMAN Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.[1] [2] [3]

See Also

References

  1. ↑ Gauthier-Campbell C, Bredt DS, Murphy TH, El-Husseini Ael-D. Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. Mol Biol Cell. 2004 May;15(5):2205-17. Epub 2004 Feb 20. PMID:14978216 doi:10.1091/mbc.E03-07-0493
  2. ↑ Oceguera-Yanez F, Kimura K, Yasuda S, Higashida C, Kitamura T, Hiraoka Y, Haraguchi T, Narumiya S. Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis. J Cell Biol. 2005 Jan 17;168(2):221-32. Epub 2005 Jan 10. PMID:15642749 doi:10.1083/jcb.200408085
  3. ↑ Modzelewska K, Newman LP, Desai R, Keely PJ. Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas. J Biol Chem. 2006 Dec 8;281(49):37527-35. Epub 2006 Oct 12. PMID:17038317 doi:10.1074/jbc.M604342200

3qbv, resolution 2.65Å

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