4e11: Difference between revisions

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New page: '''Unreleased structure''' The entry 4e11 is ON HOLD until Paper Publication Authors: Han, Q., Robinson, H., Li, J. Description: Crystal structure of kynurenine formamidase from Drosop...
 
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'''Unreleased structure'''


The entry 4e11 is ON HOLD  until Paper Publication
==Crystal structure of kynurenine formamidase from Drosophila melanogaster==
 
<StructureSection load='4e11' size='340' side='right'caption='[[4e11]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
Authors: Han, Q., Robinson, H., Li, J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4e11]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E11 FirstGlance]. <br>
Description: Crystal structure of kynurenine formamidase from Drosophila melanogaster
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e11 OCA], [https://pdbe.org/4e11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e11 RCSB], [https://www.ebi.ac.uk/pdbsum/4e11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e11 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KFA_DROME KFA_DROME] Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Required for elimination of toxic metabolites.[HAMAP-Rule:MF_03014]<ref>PMID:22690733</ref> <ref>PMID:83140</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Han Q]]
[[Category: Li J]]
[[Category: Robinson H]]

Latest revision as of 17:49, 14 March 2024

Crystal structure of kynurenine formamidase from Drosophila melanogasterCrystal structure of kynurenine formamidase from Drosophila melanogaster

Structural highlights

4e11 is a 1 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KFA_DROME Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Required for elimination of toxic metabolites.[HAMAP-Rule:MF_03014][1] [2]

References

  1. ↑ Han Q, Robinson H, Li J. Biochemical identification and crystal structure of kynurenine formamidase from Drosophila melanogaster. Biochem J. 2012 Jun 12. PMID:22690733 doi:10.1042/BJ20120416
  2. ↑ Moore GP, Sullivan DT. Biochemical and genetic characterization of kynurenine formamidase from Drosophila melanogaster. Biochem Genet. 1978 Aug;16(7-8):619-34. PMID:83140

4e11, resolution 2.00Å

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