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New page: '''Unreleased structure''' The entry 3vpn is ON HOLD Authors: Chen, X., Xu, Z., Liu, H., Zhang, L., Chen, B., Zhu, L., Yang, C., Zhu, W., Shao, J. Description: Crystal structure of hum... |
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==Crystal structure of human ribonucleotide reductase subunit M2 (hRRM2) mutant== | |||
<StructureSection load='3vpn' size='340' side='right'caption='[[3vpn]], [[Resolution|resolution]] 2.25Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3vpn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VPN FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vpn OCA], [https://pdbe.org/3vpn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vpn RCSB], [https://www.ebi.ac.uk/pdbsum/3vpn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vpn ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RIR2_HUMAN RIR2_HUMAN] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. | |||
==See Also== | |||
*[[Ribonucleotide reductase 3D structures|Ribonucleotide reductase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chen B]] | |||
[[Category: Chen X]] | |||
[[Category: Liu H]] | |||
[[Category: Shao J]] | |||
[[Category: Xu Z]] | |||
[[Category: Yang C]] | |||
[[Category: Zhang L]] | |||
[[Category: Zhu L]] | |||
[[Category: Zhu W]] | |||
Latest revision as of 15:31, 8 November 2023
Crystal structure of human ribonucleotide reductase subunit M2 (hRRM2) mutantCrystal structure of human ribonucleotide reductase subunit M2 (hRRM2) mutant
Structural highlights
FunctionRIR2_HUMAN Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. See Also |
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