4dix: Difference between revisions

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==Crystal structure of the Ig-PH domain of actin-binding protein SCAB1==
The line below this paragraph, containing "STRUCTURE_4dix", creates the "Structure Box" on the page.
<StructureSection load='4dix' size='340' side='right'caption='[[4dix]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[4dix]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DIX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
{{STRUCTURE_4dix|  PDB=4dix  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dix OCA], [https://pdbe.org/4dix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dix RCSB], [https://www.ebi.ac.uk/pdbsum/4dix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dix ProSAT]</span></td></tr>
 
</table>
===Crystal structure of the Ig-PH domain of actin-binding protein SCAB1===
== Function ==
 
[https://www.uniprot.org/uniprot/SCAB1_ARATH SCAB1_ARATH] Plant-specific actin binding protein that bundles and stabilizes microfilaments (MFs). Has no nucleation or capping activity. Regulates MF reorganization during stomatal closure. The binding to F-actin is insensitive to Ca(2+) and pH. Binds weakly to inositol phosphates (PubMed:22356912).<ref>PMID:21719691</ref> <ref>PMID:22356912</ref>
 
== References ==
==About this Structure==
<references/>
[[4dix]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DIX OCA].  
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
[[Category: Ye, K.]]
[[Category: Large Structures]]
[[Category: Zhang, W.]]
[[Category: Ye K]]
[[Category: Beta sheet]]
[[Category: Zhang W]]
[[Category: Cytosolic]]
[[Category: Ig domain]]
[[Category: Malonate ion]]
[[Category: Ph domain]]
[[Category: Ph superfold]]
[[Category: Protein binding]]

Latest revision as of 11:48, 20 March 2024

Crystal structure of the Ig-PH domain of actin-binding protein SCAB1Crystal structure of the Ig-PH domain of actin-binding protein SCAB1

Structural highlights

4dix is a 2 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.7Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SCAB1_ARATH Plant-specific actin binding protein that bundles and stabilizes microfilaments (MFs). Has no nucleation or capping activity. Regulates MF reorganization during stomatal closure. The binding to F-actin is insensitive to Ca(2+) and pH. Binds weakly to inositol phosphates (PubMed:22356912).[1] [2]

References

  1. ↑ Zhao Y, Zhao S, Mao T, Qu X, Cao W, Zhang L, Zhang W, He L, Li S, Ren S, Zhao J, Zhu G, Huang S, Ye K, Yuan M, Guo Y. The plant-specific actin binding protein SCAB1 stabilizes actin filaments and regulates stomatal movement in Arabidopsis. Plant Cell. 2011 Jun;23(6):2314-30. doi: 10.1105/tpc.111.086546. Epub 2011 Jun, 30. PMID:21719691 doi:http://dx.doi.org/10.1105/tpc.111.086546
  2. ↑ Zhang W, Zhao Y, Guo Y, Ye K. Plant actin-binding protein SCAB1 is dimeric actin cross-linker with atypical pleckstrin homology domain. J Biol Chem. 2012 Apr 6;287(15):11981-90. Epub 2012 Feb 22. PMID:22356912 doi:10.1074/jbc.M111.338525

4dix, resolution 1.70Å

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