3v44: Difference between revisions

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-[[Image:3v44.jpg|left|200px]]
-<!--
+==Crystal structure of the N-terminal fragment of zebrafish TLR5==
-The line below this paragraph, containing "STRUCTURE_3v44", creates the "Structure Box" on the page.
+<StructureSection load='3v44' size='340' side='right'caption='[[3v44]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3v44]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V44 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.83&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-{{STRUCTURE_3v44|  PDB=3v44  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v44 OCA], [https://pdbe.org/3v44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v44 RCSB], [https://www.ebi.ac.uk/pdbsum/3v44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v44 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/B3DIN1_DANRE B3DIN1_DANRE] [https://www.uniprot.org/uniprot/Q4G1L2_EPTBU Q4G1L2_EPTBU]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Toll-like receptor 5 (TLR5) binding to bacterial flagellin activates signaling through the transcription factor NF-kappaB and triggers an innate immune response to the invading pathogen. To elucidate the structural basis and mechanistic implications of TLR5-flagellin recognition, we determined the crystal structure of zebrafish TLR5 (as a variable lymphocyte receptor hybrid protein) in complex with the D1/D2/D3 fragment of Salmonella flagellin, FliC, at 2.47 angstrom resolution. TLR5 interacts primarily with the three helices of the FliC D1 domain using its lateral side. Two TLR5-FliC 1:1 heterodimers assemble into a 2:2 tail-to-tail signaling complex that is stabilized by quaternary contacts of the FliC D1 domain with the convex surface of the opposing TLR5. The proposed signaling mechanism is supported by structure-guided mutagenesis and deletion analyses on CBLB502, a therapeutic protein derived from FliC.
-===The crystal structure of an immune receptor===
+Structural basis of TLR5-flagellin recognition and signaling.,Yoon SI, Kurnasov O, Natarajan V, Hong M, Gudkov AV, Osterman AL, Wilson IA Science. 2012 Feb 17;335(6070):859-64. PMID:22344444<ref>PMID:22344444</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3v44" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_22344444}}, adds the Publication Abstract to the page
+*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 22344444 is the PubMed ID number.
+*[[Variable lymphocyte receptor 3D structures|Variable lymphocyte receptor 3D structures]]
--->
+== References ==
-{{ABSTRACT_PUBMED_22344444}}
+<references/>
+__TOC__
-==About this Structure==
+</StructureSection>
-[[3v44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio,_eptatretus_burgeri Danio rerio, eptatretus burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V44 OCA].
+[[Category: Danio rerio]]
+[[Category: Eptatretus burgeri]]
-==Reference==
+[[Category: Large Structures]]
-<ref group="xtra">PMID:022344444</ref><references group="xtra"/>
+[[Category: Hong H]]
-[[Category: Danio rerio, eptatretus burgeri]]
+[[Category: Wilson IA]]
-[[Category: Hong, H.]]
+[[Category: Yoon SI]]
-[[Category: Wilson, I A.]]
-[[Category: Yoon, S I.]]
-[[Category: Flagellin]]
-[[Category: Immune system]]
-[[Category: Innate immune receptor]]
-[[Category: Innate immunity]]
-[[Category: Leucine-rich repeat]]