3b93: Difference between revisions
New page: left|200px<br /><applet load="3b93" size="350" color="white" frame="true" align="right" spinBox="true" caption="3b93, resolution 2.2Å" /> '''crystal structure of ... |
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== | ==crystal structure of human GITRL== | ||
<StructureSection load='3b93' size='340' side='right'caption='[[3b93]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
[[ | == Structural highlights == | ||
[[ | <table><tr><td colspan='2'>[[3b93]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B93 FirstGlance]. <br> | ||
[[ | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3b94|3b94]]</div></td></tr> | ||
[[ | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNFSF18, AITRL, GITRL, TL6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b93 OCA], [https://pdbe.org/3b93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b93 RCSB], [https://www.ebi.ac.uk/pdbsum/3b93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b93 ProSAT]</span></td></tr> | ||
[ | </table> | ||
[[ | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/TNF18_HUMAN TNF18_HUMAN]] Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B.<ref>PMID:17449724</ref> <ref>PMID:18040044</ref> | ||
[ | == Evolutionary Conservation == | ||
[[ | [[Image:Consurf_key_small.gif|200px|right]] | ||
[ | Check<jmol> | ||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b9/3b93_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b93 ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Tumor necrosis factor ligand superfamily 3D structures|Tumor necrosis factor ligand superfamily 3D structures]] | |||
*[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Human]] | |||
[[Category: Large Structures]] | |||
[[Category: Song, X M]] | |||
[[Category: Zhou, Z C]] | |||
[[Category: Asymmetric]] | |||
[[Category: C2 spacegroup]] | |||
[[Category: Cytokine]] | |||
[[Category: Glycoprotein]] | |||
[[Category: Membrane]] | |||
[[Category: Open trimer]] | |||
[[Category: Signal-anchor]] | |||
[[Category: Transmembrane]] | |||
