3s68: Difference between revisions

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-[[Image:3s68.png|left|200px]]
-<!--
+==Rat COMT in complex with SAM and Tolcapone at 1.85A, P3221, Rfree=22.0==
-The line below this paragraph, containing "STRUCTURE_3s68", creates the "Structure Box" on the page.
+<StructureSection load='3s68' size='340' side='right'caption='[[3s68]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3s68]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S68 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TCW:TOLCAPONE'>TCW</scene></td></tr>
-{{STRUCTURE_3s68|  PDB=3s68  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s68 OCA], [https://pdbe.org/3s68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s68 RCSB], [https://www.ebi.ac.uk/pdbsum/3s68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s68 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/COMT_RAT COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
-===Rat COMT in complex with SAM and Tolcapone at 1.85A, P3221, Rfree=22.0===
+==See Also==
+*[[Catechol O-methyltransferase 3D structures|Catechol O-methyltransferase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-[[3s68]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S68 OCA].
+[[Category: Large Structures]]
-[[Category: Catechol O-methyltransferase]]
 [[Category: Rattus norvegicus]]
-[[Category: Rudolph, M G.]]
+[[Category: Benz J]]
-[[Category: Methyltransferase]]
+[[Category: Ehler A]]
-[[Category: Neurotransmitter degradation]]
+[[Category: Rudolph MG]]
-[[Category: Transferase-transferase inhibitor complex]]
+[[Category: Schlatter D]]
+[[Category: Stihle M]]