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| [[Image:1mo8.png|left|200px|thumb|NMR Structure of ATPase [[1mo8]]]]
| | <StructureSection load='RuvBL12_12mer.pdb' size='400' side='right' scene='Journal:JSB:1/Cv/2' caption='An ATPase, Human RuvB-like 1 dodecamer complex with ADP (PDB code [[2c9o]])'> |
| {{STRUCTURE_1mo8| PDB=1mo8 | SIZE=300| SCENE=ATPase/Cv/1 |right|CAPTION=ATPase complexed with ATP [[1mo8]] }}
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| [[ATPase]] is an enzyme which catalyzes the breakdown of ATP into ADP and a phosphate ion. This dephosphorylation releases energy which the enzyme uses to drive other reactions. Vacuolar-type H+ ATPase (V-ATPase) couples the energy to proton transport across membranes. The images at the left and at the right correspond to one representative ATPase, ''i.e.'' the NMR structure of rat ATPase ([[1mo8]]). Details on Cu transporting ATPase are in [[P(1B)-Type Cu(I) Transporting ATPases ATP7A and ATP7B]]. Details on Na/K transporting ATPase are in [[Sodium-Potassium ATPase]].
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| {{TOC limit|limit=2}}
| | [[ATPase]] is an enzyme which catalyzes the breakdown of [[ATP]] into ADP and a phosphate ion. This dephosphorylation releases energy which the enzyme uses to drive other reactions<ref>PMID:15078220</ref>. The F1/0 ATPase is called '''ATP synthase''' synthesises the reverse reaction, i.e., the addition of phosphate to ADP to form ATP<ref>PMID:30888962</ref>. ATPase types include:<br /> |
| | * '''F-ATPase''' - the prime producers of ATP<ref>PMID:8065448</ref>. For details see [[Alice Clark/ATPsynthase]];<br /> <!--Should there be a F-ATPase page for this like thee is for V-ATPase below? If one is made, I'd like to see links to the animations/movies referenced at https://twitter.com/NathanRoberts17/status/943428752113094656 there.--> |
| | * '''V-ATPase''' or Vacuolar-type H+ ATPase couples the energy to proton transport across membranes. |
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| == 3D Structures of ATPase ==
| | ATPase is inhibited by [[Bedaquiline]] which is used as TB drug<ref>PMID:28807917</ref>. |
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| ''Update November 2011'' | | For details see [[V-ATPase]];<br /> |
| | * '''A-ATPase''' are found in archaea. For details see [[A-ATP Synthase]];<br /> |
| | * '''P-ATPase''' transport ions<ref>PMID:20962537</ref><br /> |
| | * '''E-ATPase''' hydrolyze extracellular ATP<ref>PMID:7721538</ref>. <br /> |
| | * '''MipZ''' is an ATPase which forms a complex with the chromosome partitioning protein ParB and is responsible for the regulation of FtsZ ring formation.<br /> |
| | ATPase domains include metal-binding domain (MBD) and nucleotide-binding domain (NBD). For more details see:<br /> |
| | * '''ATPase RavA''' participates in the pathway which response to ahminoglycosides under anaerobic conditions and cell membrane regulation<ref>PMID:36127320</ref>. <br /> |
| | * '''ATPase InvC''' energizes the apparatus needed for the entry of ''Salmonella typhimurium'' into mammalian cells<ref>PMID:8045880</ref>. <br /> |
| | * '''Peroxisomal ATPase''' Pex1/Pex6 is essential for peroxisome formation<ref>PMID:37741838</ref>. <br /> |
| | * '''INO8o ATPase''' is a component of the chromatin remodelling complex<ref>PMID:19062292</ref>. <br /> |
| | *'''Cu transporting ATPase''' are in [[P(1B)-Type Cu(I) Transporting ATPases ATP7A and ATP7B]].<br /> |
| | *'''Na/K transporting ATPase''' are in [[Sodium-Potassium ATPase]].<br /> |
| | *'''H/K transporting ATPase''' are in [[Esomeprazole and H+/K+ - ATPase Interaction]].<br /> |
| | *'''Transitional endoplasmic reticulum ATPase''' are in [[Valosin Containing Protein D120]].<br /> |
| | *'''Central stalk in F(1)-ATPase''' is described in [[A-ATP Synthase]]<br /> |
| | *[[Journal:JSB:1|RuvBL1/RuvBL2 complex (ATPase)]]<br /> |
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| === Cu transporting ATPase ===
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| [[2kmv]], [[2kmx]], [[2arf]] – hATPase NBD – human – NMR<br />
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| [[2kij]] - hATPase MBD – NMR<br />
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| [[1yjr]], [[1yjt]], [[1yju]], [[1yjv]] - hATPase (mutant) 6th soluble domain – NMR<br />
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| [[1y3j]], [[1y3k]] - hATPase 5th soluble domain – NMR<br />
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| [[1s6o]], [[1s6u]] - hATPase 2nd soluble domain – NMR<br />
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| [[1q8l]] - hATPase 2nd MBD – NMR<br />
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| [[1aw0]], [[2aw0]] - hATPase 4th MBD – NMR<br />
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| [[1kvi]], [[1kvj]] - hATPase 1st MBD – NMR<br />
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| [[3dxs]] - AtATPase MBD – ''Arabidopsis thaliana''<br />
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| [[2k1r]] - hATPase MBD+ ATOX1 – NMR<br />
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| [[2rop]], [[2g9o]], [[2ga7]] - hATPase MBD – NMR<br />
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| [[2rml]] - BsATPase N-terminal – ''Bacillus subtilis'' – NMR<br />
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| [[2gcf]] - sATPase N-terminal - Synechocystis – NMR<br />
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| [[2iye]] - ATPase catalytic fragment – ''Sulfolobus solfataricus''<br />
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| [[1fvq]], [[1fvs]] - hATPase – NMR<br />
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| [[3cjk]] – hATPase + Cu transporting protein ATX1<br />
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| [[3rfu]] – ATPase – ''Legionella pneumophila''
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| === Na/K transporting ATPase ===
| | </StructureSection> |
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| [[3a3y]] - SaATPase+K+ouabain – ''Squalus acanthias''<br />
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| [[3kdp]], [[3b8e]] – pATPase – pig <br />
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| [[3n23]] – pATPase + ouabain<br />
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| [[3b8e]] - pATPase a+BeF3 <br />
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| [[2hc8]] –AfATPase CopA A domain<br />
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| [[2b8e]] - AfATPase CopA NBD<br />
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| [[2xze]] - SaATPase<br />
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| [[1mo8]], [[1mo7]] - ATPase α-1 – rat<br />
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| [[1q3i]] - pATPase NBD<br />
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| [[3n2f]] - pATPase subunits α,β,γ<br />
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| [[2zxe]] - ATPase subunits α,β + phospholemman-like protein – spiny dogfish
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| === Ca transporting ATPase === | | ==3D Printed Physical Model of ATP Synthase== |
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| [[3fgo]] - rATPase+CPA+AMPPCP – rabbit<br />
| | Shown below is a 3D printed physical model of the Respiration Electron Transport Chain. Complex I is colored red, complex II is purple, complex III is green, complex IV is blue and the atp synthase protein is colored orange, yellow and red. |
| [[3b9r]], [[1xp5]] - rATPase+AlF4<br />
| | [[Image:atpSynthase1_centerForBioMolecularModeling.jpg |550px]] |
| [[1wpg]] - rATPase+MgF4<br />
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| [[2zbe]], [[3b9b]] – rATPase+BeF3<br />
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| [[2zbf]] - rATPase+BeF3+TG<br />
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| [[2zbg]] - rATPase+AlF4+TG<br />
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| [[2zbd]], [[3ar8]] - rATPase+AlF4+nucleotide+Ca<br />
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| [[3ar9]] - rATPase+BeF3+nucleotide<br />
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| [[2dqs]], [[3ar2]], [[1vfp]] - rATPase+AMPPCP<br />
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| [[2c88]], [[2c8k]], [[3ar4]], [[3ar3]], [[3ar5]], [[3ar7]] - rATPase+nucleotide+TG<br />
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| [[2ear]], [[2c8l]] - rATPase+TG<br />
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| [[1iwo]] - rATPase<br /> | |
| [[2agv]] - rATPase+TG+BHQ<br />
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| [[2eas]] - rATPase+CPA<br />
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| [[2eat]] - rATPase+CPA+GT<br />
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| [[3ar6]] - rATPase+TNP-ADP+GT<br />
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| [[2eau]] - rATPase+CPA+curcumin<br />
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| [[3ba6]] - rATPase phosphoenzyme intermediate<br />
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| [[3fpb]] - rATPase+ATP+cyclopiazonic acid<br />
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| [[3fps]], [[2oa0]] - rATPase+ADP+cyclopiazonic acid<br />
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| [[2o9j]] - rATPase+MgF4+cyclopiazonic acid<br />
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| [[1kju]], [[3n5k]] - rATPase E2 state<br />
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| [[2c9m]] - rATPase Ca2E1 state<br />
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| [[1t5s]], [[3n8g]] - rATPase Ca2E1 state+AMPPCP<br />
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| [[1t5t]] - rATPase Ca2E1 state+ADP+AlF4<br />
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| [[1su4]] - rATPase +2Ca2<br />
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| [[2by4]], [[2yfy]], [[3nal]], [[3nam]], [[3nan]] - rATPase HNE2 state+thapsigargin derivative
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| === Zn transporting ATPase === | | ====The MSOE Center for BioMolecular Modeling==== |
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| [[2ofg]], [[2ofh]] - sATPase N-terminal – NMR | | [[Image:CbmUniversityLogo.jpg | left | 150px]] |
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| | The [http://cbm.msoe.edu MSOE Center for BioMolecular Modeling] uses 3D printing technology to create physical models of protein and molecular structures, making the invisible molecular world more tangible and comprehensible. To view more protein structure models, visit our [http://cbm.msoe.edu/educationalmedia/modelgallery/ Model Gallery]. |
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| === K+ transporting ATPase === | | == 3D Structures of ATPase == |
| | | [[ATPase 3D structures]] |
| [[2a00]], [[2a29]] - EcATPase NBD of KdpB+AMPPNP– ''Escherichia coli'' – NMR<br />
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| [[1svj]], [[1u7q]] - EcATPase NBD of KdpB – NMR
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| === As+ transporting ATPase ===
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| [[1ii0]], [[1f48]] - EcATPase<br />
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| [[1ihu]] – EcATPase+Mg+ADP+AlF3<br />
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| [[1ii9]] - EcATPase<br />
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| [[3h84]], [[3idq]], [[3a36]], [[3a37]] - yATPase GET3 – yeast<br />
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| [[3sja]], [[3sjb]], [[3sjc]], [[3sjd]], [[3zs8]], [[3zs9]] - yATPase GET3 + GET1 cystolic domain<br />
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| [[3ibg]] - ATPase GET3 – ''Aspergillus fumigatus''
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| === H+ transporting ATPase ===
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| [[3b8c]] - AtATPase C terminal truncated<br />
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| [[1mhs]] - ATPase – ''Neurospora crassa''<br />
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| [[2kz9]] – yATPase V-type
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| === Na+ transporting ATPase ===
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| [[2db4]], [[3aou]] - EhATPase subunit K – ''Enterococcus hirae''<br />
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| [[3aon]] - EhATPase subunits D,G<br />
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| [[1yce]] - ATPase rotor ring – ''Ilyobacter tartaricus''
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| === H/K transporting ATPase ===
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| [[1iwc]], [[1iwf]] - pATPase NBD <br />
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| [[3ixz]] - pATPase a+AlF4<br />
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| [[2xzb]] – pATPase subunits α, β<br />
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| === Mg++ transporting ATPase ===
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| [[3gwi]] – EcATPase P-1 NBD
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| === Arg/ornithine transporting ATPase ===
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| [[3md0]] – MtATPase+GDP – ''Mycobacterium tuberculosis''<br />
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| [[1kmh]] - ATPase alpha subunit+tentoxin – spinach<br />
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| [[1h8e]] – cATPase+ADP+AlF4+ADP+SO4 - cow<br />
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| [[1h8h]] - cATPase+ AMPPNP<br />
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| [[1efr]] - cATPase+efrapeptin<br /> | |
| [[3fks]] – ATPase – yeast<br />
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| [[3ea0]] – ATPase ParA, fragment – ''Chlorobium tepidum''<br />
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| [[2qen]] – ATPase (mutant) Walker-type – ''Pyrococcus abyssi''<br />
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| [[3cf0]], [[3cf1]], [[3cf3]] – mATPase NBD+ADP – mouse<br />
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| [[3cf2]] - mATPase NBD+ADP+AMP-PNP<br />
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| [[2r31]], [[2p4x]] – PdATPase ATP12 – ''Paracoccus denitrificans''<br />
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| [[2zd2]] – PdATPase (mutant) ATP12<br />
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| [[1d8s]] – EcATPase F1<br />
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| [[1vdz]] – PhATPase subunit A – ''Pyrococcus horikoshii''<br />
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| ===P-ATPase Cu transporting===
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| [[3j08]], [[3j09]] - AfATPase<br />
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| [[3a1c]] – AfATPase + AMPPCP<br />
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| [[3a1d]] - AfATPase + ADP-Mg<br / >
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| [[3a1e]] - AfATPase (mutant) + AMPPCP
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| ===RNA-dependent ATPase===
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| [[3eaq]], [[3i31]], [[3i32]] – TtATPase fragment<br />
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| [[3mwj]] – TtATPase N-terminal (mutant)<br />
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| [[3mwk]], [[3nbf]] – TtATPase N-terminal + 8-oxo-AMP<br />
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| [[3mwl]] - TtATPase N-terminal (mutant) + 8-oxoadenine<br />
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| [[3nej]] - TtATPase reca-like domain (mutant)
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| ===Proteasome-associated ATPase===
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| [[3fp9]], [[3m9b]], [[3m9h]] – MtATPase intern domain<br />
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| [[3m91]], [[3m9d]] - MtATPase coiled coil domain + protein PUP<br />
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| [[3kw6]] – hATPase 5
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| ===Transitional endoplasmic reticulum ATPase===
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| [[3hu1]], [[3hu2]], [[3hu3]] – hTer-ATPase + ATPGS<br />
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| [[3qc8]], [[3qq8]] - hTer-ATPase N terminal + FAS-associated factor 1<br />
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| [[3qq7]] - hTer-ATPase N terminal<br />
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| [[3tiw]] - hTer-ATPase N terminal + E3 ubiquitin-protein ligase peptide
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| ===LAO/AO transport system ATPase===
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| [[3nxs]] – ATPase – ''Mycobacterium smegmatis''
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| ===DNA double-strand repair ATPase (Rad50)===
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| [[3aux]] – MjRad50 – ''Methanocaldococcus jannaschii''<br />
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| [[3auy]] - MjRad50 + ADP<br />
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| [[3av0]] - MjRad50 + ATP<br />
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| [[3qg5]] – Rad50 NBD + MRE11 – ''Thermotoga maritima''<br />
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| [[3qkr]], [[3qks]] - PfRad50 NBD + MRE11 – ''Pyrococcus furiosus''<br />
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| [[3qkt]] - PfRad50 NBD + AMPPNP<br />
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| [[3qku]] - PfRad50 NBD + AMPPNP + MRE11
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| [[3nbx]] – EcATPase Rava + ADP
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| | ==References== |
| | <references/> |
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| [[Category:Topic Page]] | | [[Category:Topic Page]] |