4aee: Difference between revisions

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-[[Image:4aee.jpg|left|200px]]
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+==CRYSTAL STRUCTURE OF MALTOGENIC AMYLASE FROM S.MARINUS==
-The line below this paragraph, containing "STRUCTURE_4aee", creates the "Structure Box" on the page.
+<StructureSection load='4aee' size='340' side='right'caption='[[4aee]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[4aee]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylothermus_marinus Staphylothermus marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AEE FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aee OCA], [https://pdbe.org/4aee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aee RCSB], [https://www.ebi.ac.uk/pdbsum/4aee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aee ProSAT]</span></td></tr>
-{{STRUCTURE_4aee|  PDB=4aee  |  SCENE=  }}
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Staphylothermus marinus maltogenic amylase (SMMA) is a novel extreme thermophile maltogenic amylase with an optimal temperature of 100 degrees C, which hydrolyzes alpha-(1-4)-glycosyl linkages in cyclodextrins and in linear malto-oligosaccharides. This enzyme has a long N-terminal extension that is conserved among archaic hyperthermophilic amylases but is not found in other hydrolyzing enzymes from the glycoside hydrolase 13 family. The SMMA crystal structure revealed that the N-terminal extension forms an N' domain that is similar to carbohydrate-binding module 48, with the strand-loop-strand region forming a part of the substrate binding pocket with several aromatic residues, including Phe-95, Phe-96, and Tyr-99. A structural comparison with conventional cyclodextrin-hydrolyzing enzymes revealed a striking resemblance between the SMMA N' domain position and the dimeric N domain position in bacterial enzymes. This result suggests that extremophilic archaea that live at high temperatures may have adopted a novel domain arrangement that combines all of the substrate binding components within a monomeric subunit. The SMMA structure provides a molecular basis for the functional properties that are unique to hyperthermophile maltogenic amylases from archaea and that distinguish SMMA from moderate thermophilic or mesophilic bacterial enzymes.
-===CRYSTAL STRUCTURE OF MALTOGENIC AMYLASE FROM S.MARINUS===
+Association of Novel Domain in Active Site of Archaic Hyperthermophilic Maltogenic Amylase from Staphylothermus marinus.,Jung TY, Li D, Park JT, Yoon SM, Tran PL, Oh BH, Janecek S, Park SG, Woo EJ, Park KH J Biol Chem. 2012 Mar 9;287(11):7979-89. Epub 2012 Jan 5. PMID:22223643<ref>PMID:22223643</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 4aee" style="background-color:#fffaf0;"></div>
-==About this Structure==
+==See Also==
-[[4aee]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylothermus_marinus Staphylothermus marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEE OCA].
+*[[Amylase 3D structures|Amylase 3D structures]]
-[[Category: Glucan 1,4-alpha-maltohydrolase]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Staphylothermus marinus]]
-[[Category: Jung, T Y.]]
+[[Category: Jung TY]]
-[[Category: Park, C H.]]
+[[Category: Park CH]]
-[[Category: Park, K H.]]
+[[Category: Park KH]]
-[[Category: Park, S H.]]
+[[Category: Park SH]]
-[[Category: Woo, E J.]]
+[[Category: Woo EJ]]
-[[Category: Yoon, S M.]]
+[[Category: Yoon SM]]
-[[Category: Cyclodextrin hydrolase]]
-[[Category: Gh13]]
-[[Category: Hydrolase]]
-[[Category: Hyperthermostable]]