3v34: Difference between revisions

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'''Unreleased structure'''


The entry 3v34 is ON HOLD
==Crystal structure of MCPIP1 conserved domain with magnesium ion in the catalytic center==
<StructureSection load='3v34' size='340' side='right'caption='[[3v34]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3v34]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V34 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.003&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v34 OCA], [https://pdbe.org/3v34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v34 RCSB], [https://www.ebi.ac.uk/pdbsum/3v34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v34 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ZC12A_HUMAN ZC12A_HUMAN] Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA (By similarity). Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19.<ref>PMID:16574901</ref> <ref>PMID:18364357</ref> <ref>PMID:22561375</ref>


Authors: Xu, J., Peng, W., Sun, Y., Wang, X., Xu, Y., Li, X., Gao, G., Rao, Z.
==See Also==
 
*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
Description: Crystal structure of MCPIP1 conserved domain with magnesium ion in the catalytic center
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Gao G]]
[[Category: Li X]]
[[Category: Peng W]]
[[Category: Rao Z]]
[[Category: Sun Y]]
[[Category: Wang X]]
[[Category: Xu J]]
[[Category: Xu Y]]

Latest revision as of 11:39, 20 March 2024

Crystal structure of MCPIP1 conserved domain with magnesium ion in the catalytic centerCrystal structure of MCPIP1 conserved domain with magnesium ion in the catalytic center

Structural highlights

3v34 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.003Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ZC12A_HUMAN Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA (By similarity). Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19.[1] [2] [3]

See Also

References

  1. Zhou L, Azfer A, Niu J, Graham S, Choudhury M, Adamski FM, Younce C, Binkley PF, Kolattukudy PE. Monocyte chemoattractant protein-1 induces a novel transcription factor that causes cardiac myocyte apoptosis and ventricular dysfunction. Circ Res. 2006 May 12;98(9):1177-85. Epub 2006 Mar 30. PMID:16574901 doi:http://dx.doi.org/10.1161/01.RES.0000220106.64661.71
  2. Niu J, Azfer A, Zhelyabovska O, Fatma S, Kolattukudy PE. Monocyte chemotactic protein (MCP)-1 promotes angiogenesis via a novel transcription factor, MCP-1-induced protein (MCPIP). J Biol Chem. 2008 May 23;283(21):14542-51. doi: 10.1074/jbc.M802139200. Epub 2008, Mar 24. PMID:18364357 doi:http://dx.doi.org/10.1074/jbc.M802139200
  3. Xu J, Peng W, Sun Y, Wang X, Xu Y, Li X, Gao G, Rao Z. Structural study of MCPIP1 N-terminal conserved domain reveals a PIN-like RNase. Nucleic Acids Res. 2012 May 4. PMID:22561375 doi:10.1093/nar/gks359

3v34, resolution 2.00Å

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